Synthesis, Spectral Characterization and Antimicrobial Evaluation of Schiff Base Cu(II), Ni(II) and Co(II) Novel Macrocyclic Complexes

Kumar, Gajendra; Kumar, Amit; Shishodia, Nupur; Garg, Yashi; Yadav, Bikarama Prasad

doi:10.1155/2011/497279

Cited by 8 publications

(2 citation statements)

References 23 publications

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“…and penicillium sp. [43]. The Schiff bases and their complexes have been screened for their antifungal activities against Aspergillus niger, Aspergillus flavus, and Cladosporium.…”

Section: Antifungal Activitymentioning

confidence: 99%

Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

Bitu¹,

Hossain²,

Zahid³

et al. 2019

AJHC

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Metals contribute important roles in biological system. It is recognized that metals are highly linked in cellular and subcellular functions. With the application of novel and experienced tools to study biological and biochemical systems the true role of inorganic salts in biological systems can be studied. Schiff base metal complexes show a broad range of biological activity. The activity of Schiff base ligand is usually increased by complexation with the metal ion. The copper complexes of Schiff bases have striking properties such as antibacterial, antifungal, antiviral, anti-inflammatory, anti-tumor and cytotoxic activities, plant development controller, enzymatic activity and applications in pharmaceutical fields. The divalent cations Zn 2+, Ca 2+ and Mg 2+ prevent cytotoxicity and in vivo antagonize Cd-induced carcinogenesis. Lack of body iron is common in cancer patients and it is associated with complications in surgery and in animal experiments. The transport of iron and other metal ions by the blood plasma is achieved through the formation of protein complexes. Copper is placed as a vital metalloelement and is primarily connected with copper-dependent cellular enzymes. Metals are also used as inorganic drugs for many diseases. In this review our main focused on research undertaken for biological activity study of Cu(II) metal complexes containing Schiff bases over the past few decades.

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“…and penicillium sp. [43]. The Schiff bases and their complexes have been screened for their antifungal activities against Aspergillus niger, Aspergillus flavus, and Cladosporium.…”

Section: Antifungal Activitymentioning

confidence: 99%

Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

Bitu¹,

Hossain²,

Zahid³

et al. 2019

AJHC

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show abstract

“…e.g. as anticancer agent 13 , as bactericides 14 , antiviral agents 15 and fungicides 16,17 . The binding capacity of Schiff bases to metals has been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic, Antitumor and Antimicrobial Studies of an Oxygen and Nitrogen Donor, Novel Schiff Base Ligand, Acetoacetanilide-(1,2-Ethylenediimine) Ethylacetoacetate and Its Transition Metal Complexes

K¹,

Varma²,

Reena³

et al. 2017

Int. Res. J. Pharm.

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The Schiff base, acetoacetanilide-(1, 2-ethylediimine)ethylacetoacetate (AcEE) and its six transition metal compounds were synthesized, characterised and tested for their Cytotoxic, anticancer, antitumor, antimicrobial activities. The ligand AcEE synthesized from acetoacetanilied and ethylacetoacetate with ethylenediamine. Daltons Lymphoma Ascites cell (DLA) induced solid and Ehrliche`s Ascites Carcinoma cell (EAC) induced ascites tumour models were used for antitumor studies of the compounds. The ligand, AcEE and its complexes were screened against C. albicans, C. Tropicalis and A. Flavus fungi and Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Bacillus cereus bacteria to evaluate their potential antimicrobial activities. The resultant data are quite propitiating. The copper complex was found to have higher IC50 value, 49 µ/ml. Thus, it was found that the AcEE of Cu(II) complex was effective in raising the average life span of the tumour enduring mice by 36.6, 17.9 and 13.6 % at 5, 10 and 15 mg/kg doses respectively It is clear from the antifungal screening data that the metal complexes are more fungitoxic than the chelating agent itself. The antibacterial activity results revealed that the ligand, AcEE has more sensitive and potent for gram-positive than gram-negative bacteria.The Schiff base, AcEE and its six transition metal complexes were synthesized, characterised and tested for their Cytotoxic, anticancer, antitumor, antimicrobial activities. The complexes especially Cu(II) AcEE was found most active among all the synthesised compounds.

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Synthesis and antityrosinase, antioxidant activities of phloretin thiosemicarbazones

Wan

et al. 2013

Res Chem Intermed

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Synthesis, Spectral Characterization and Antimicrobial Evaluation of Schiff Base Cu(II), Ni(II) and Co(II) Novel Macrocyclic Complexes

Cited by 8 publications

References 23 publications

Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

Cytotoxic, Antitumor and Antimicrobial Studies of an Oxygen and Nitrogen Donor, Novel Schiff Base Ligand, Acetoacetanilide-(1,2-Ethylenediimine) Ethylacetoacetate and Its Transition Metal Complexes

Synthesis and antityrosinase, antioxidant activities of phloretin thiosemicarbazones

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