Anti-pathogenic Activity of Cu(II) Complexes Incorporating Schiff Bases: A Short Review

Abstract

Metals contribute important roles in biological system. It is recognized that metals are highly linked in cellular and subcellular functions. With the application of novel and experienced tools to study biological and biochemical systems the true role of inorganic salts in biological systems can be studied. Schiff base metal complexes show a broad range of biological activity. The activity of Schiff base ligand is usually increased by complexation with the metal ion. The copper complexes of Schiff bases have striking properties such as antibacterial, antifungal, antiviral, anti-inflammatory, anti-tumor and cytotoxic activities, plant development controller, enzymatic activity and applications in pharmaceutical fields. The divalent cations Zn 2+, Ca 2+ and Mg 2+ prevent cytotoxicity and in vivo antagonize Cd-induced carcinogenesis. Lack of body iron is common in cancer patients and it is associated with complications in surgery and in animal experiments. The transport of iron and other metal ions by the blood plasma is achieved through the formation of protein complexes. Copper is placed as a vital metalloelement and is primarily connected with copper-dependent cellular enzymes. Metals are also used as inorganic drugs for many diseases. In this review our main focused on research undertaken for biological activity study of Cu(II) metal complexes containing Schiff bases over the past few decades.

Enhanced In Vivo Wound Healing Efficacy of a Novel Hydrogel Loaded with Copper (II) Schiff Base Quinoline Complex (CuSQ) Solid Lipid Nanoparticles

“…An ideal healing agent should be able to prevent infection, hasten the healing process by modifying growth factors and cytokines as well as be favorable for cell proliferation and matrix deposition, improved re-epithelization and minimal scar formation. It has been previously noted that the coordination of the Schiff base compounds to the metal ions especially copper increased their activity against several pathogenic bacteria [29].…”

Pharmaceutical significance of Schiff bases: an overview

“…Fig. 1 General structure of Schiff bases Furthermore, the Schiff bases are significant in metal complexes due to their unique ability to form a structure holding transition central metals with the reactants of the condensation reaction as illustrated in the literature for metals like Hg(II), Gd(III), Cu(II), Co(II), Ni(II), Zn(II), Y(III), Al(III), Pb(II), and Ag(II) [35][36][37][38][39][40][41][42][43][44]. Extensive research has been conducted on Schiff bases due to their significant catalytic characteristics.…”

“…Additionally, metal complexes of these ligands with Cu(II), Fe(II), Au(III), and Mn(II) were also prepared. The synthesis of a novel benzothiazole derivative (37) was achieved by the reaction between the reactant compound and N-(benzothiazol-2-yl)-2-chloroacetamide through coupling. The spectral qualities of the subject were examined.…”

Synthesis, quantum chemical calculations, in silico and in vitro bioactivity of a sulfonamide-Schiff base derivative

“…These compounds have been widely used in the medicinal and industrial fields [ 5 , 6 ]. Numerous Schiff bases exhibit a wide range of pharmacological activities, such as antibacterial, antifungal, antimalarial, antiviral, antitumor, antiproliferative, antituberculosis, anticancer, and anti-inflammatory activities [ 1 , [7] , [8] , [9] , [10] , [11] ]. These compounds have also been used as corrosion inhibitors, catalysts, chemosensors, pigments, thermally stable materials, NLO materials, and powerful chelating agents in the formation of coordination compounds [ 5 , 12 , 13 ].…”