Synthesis, Spectral Analysis and Biological Potency of Hydrazoneoxime Ligands Incorporating Pyrazolone Moiety and Their Metal Complexes

Abstract

A modest attempt has been made for the synthesis of hydrazoneoxime ligands bearing pyrazolone group (1-4) and their successive metal complexes such as: 1(a-c), 2(a-c), 3(a-c) and 4(a-c). The precursor (1Z,2E)-2-(hydroxyimino) ethanehydroximohydrazide (GH2) was obtained through coupling of (1Z,2E)-N-hydroxy-2-(hydroxyimino) ethanimidoyl chloride and hydrazinium hydroxideto generate hydrazonoxime compounds bearing the pyrazolone group. The ligands (1-4) were reacted with MX2.nH2O, where M = Co(II), Ni(II) and Cu(II) to obtain the successive metal coordinated compounds into good yields. The ligands and their metal complexes were investigated by using 1H NMR, 13C NMR, FT-IR, elemental analysis and magnetic susceptibility measurements.Tautomerism in the ligands is investigated spectroscopically and biological activities are evaluated as well. Finally, the findings of present study were found within good egreement with other workers.

Design, Synthesis, in Silico Study and Biological Evaluation of 1,8-Naphthyridine Derivatives as Potential Antibacterial Agents

“…An agar diffusion well technique was used to test the antibacterial activity of each of the recently synthesized derivatives (3a1-3a6, 3b1-3b6, and 3c1-3c6) [34][35] . The zone of inhibition was determined by a serial dilution method [36][37] . The newly synthesized compounds 3a1-3a6, 3b1-3b6, and 3c1-3c6 were found to have the greatest impact and the broadest spectrum of antibacterial activity against all tested reference bacterial strains.…”