Synthesis, self-assembly and drug release behaviors of reduction-labile multi-responsive block miktobrush quaterpolymers with linear and V-shaped grafts

Abstract

Stimuli-tunable topological/morphological transitions and drug release properties based on novel disulfide-functionalized coil–comb–coil quaterpolymers were revealed.

Dual Polymerizations: Untapped Potential for Biomaterials

“…This approach often results in a polymer with many initiating side chains, making it an attractive method to synthesize polymers with unique architectures. In all the examples described, while the first polymerization used for inimer M A varied, the pendant initiator (I B ) was almost always I ATRP . This may be because I ATRP ‐functionalized monomers are easy to synthesize for the reasons described previously.…”

“…Bottlebrush polymers with high grafting densities can also be synthesized by the inimer approach. In one example, RAFT was used to copolymerize a styrene and a maleimide‐containing monomer, the latter of which was functionalized with both I ROP and I ATRP for their respective polymerizations . In a different approach, a norbornene monomer functionalized with an I ROP and an I ATRP were polymerized by ROMP and then ROP and ATRP were subsequently initiated off the side chains .…”

“…Star polymers have also been used for imaging and diagnosis . Comb and brush polymers have been designed to contain hydrophobic regions to encapsulate and deliver paclitaxel, doxorubicin, and imaging agents, or to incorporate cationic monomers to complex with nucleic acids for gene delivery applications . Cyclic polymers have longer circulation times compared to their linear analogs and have been used as a multi‐macroinitiator in the synthesis of sunflower polymers for drug and nucleic acid delivery .…”

Styrene‐Maleimide/Maleic Anhydride Alternating Copolymers: Recent Advances and Future Perspectives

“…Along with the development of the linear S‐MA copolymers, researchers have also engineered different types of polymer brushes where the main backbone was made of S‐MA alternating copolymer and the polymeric side‐chains were fabricated mainly by incorporating chain‐transfer agents of RAFT, [ 74,75 ] ATRP initiator, [ 76,77 ] ring‐opening polymerization (ROP) initiating moiety, [ 78,79 ] and covalently attached poly(ethylene glycol) (PEG) chains. [ 80 ] A variety of polymeric architectures were developed by these polymeric brushes.…”

“…The hydrolyzed forms of S‐MA copolymers (under basic conditions) find a vast range of applications in biomedical science. The polymer is suitable to deliver hydrophobic drugs such as DOX, [ 77,94 ] and zinc protoporphyrin IX (ZnPP) [ 95 ] ( Figure ) at the tumor site. It exploits enhanced permeability and retention (EPR) effect by forming therapeutically advantageous high molecular weight S‐MA micelle‐drug conjugate.…”