Synthesis route and three different core-shell impacts on magnetic characterization of gadolinium oxide-based nanoparticles as new contrast agents for molecular magnetic resonance imaging

Azizian, Gholamreza; Alam, Nader Riahi; Haghgoo, Soheila; Moghimi, Hamid; Zohdiaghdam, Reza; Rafiei, Behrouz; Gorji, E.

doi:10.1186/1556-276x-7-549

Cited by 40 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As expected, analysis of the resulted nanoparticles showed a decrease in the percentage of gadolinium(III) and an increase of the organic component (Figure a). The presence of carbon in the “uncoated” gadolinium oxide sample is due to the diethylene glycol, which is used as a solvent in the reaction as it adsorbs onto nanoparticles surface via interactions with the hydroxyl group stabilizing the NPs in solution . The detection of nitrogen and phosphorous in the final product (i.e., GBCAs‐BP) indicated the presence of the BP derivative on the surface of the nanoparticles.…”

Section: Methodsmentioning

confidence: 99%

Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long‐Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement

Mastrogiacomo

Kownacka

Dou

et al. 2018

Adv Healthcare Materials

View full text Add to dashboard Cite

Direct in vivo monitoring of bioconstructs using noninvasive imaging modalities such as magnetic resonance imaging (MRI) or computed tomography (CT) is not possible for many materials. Calcium phosphate-based composites (CPCs) that are applicable to bone regeneration are an example where the materials have poor MRI and CT contrast; hence, they are challenging to detect in vivo. In this study, a CPC construct is designed with gadolinium-oxide nanoparticles incorporated to act as an MRI/CT multimodal contrast agent. The gadolinium(III) oxide nanoparticles are synthesized via the polyol method and surface functionalized with a bisphosphonate (BP) derivative to give a construct (gadolinium-based contrast agents (GBCAs)-BP) with strong affinity toward calcium phosphate. The CPC-GBCAs-BP functional material is longitudinally monitored after in vivo implantation in a condyle defect rat model. The synthetic method developed produces nanoparticles that are stable in aqueous solution (hydrodynamic diameter 70 nm) with significant T and T relaxivity demonstrated in both clinical 3 T and preclinical 11.7 T MRI systems. The combination of GBCAs-BP nanoparticles with CPC gives an injectable material with handling properties that are suitable for clinical applications. The BP functionalization prolongs the residence of the contrast agent within the CPC to allow long-term follow-up imaging studies. The useful contrast agent properties combined with biological compatibility indicate further investigation of the novel bone substitute hybrid material toward clinical application.

show abstract

Section: Methodsmentioning

confidence: 99%

Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long‐Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement

Mastrogiacomo

Kownacka

Dou

et al. 2018

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…In order to improve the sensitivity of MR imaging, gadolinium (Gd) based T1 contrast agent (CA) are 4 incorporated [1][2]. Commercially used Gd-chelates show low sensitivity, require high doses [3][4] and have low molecular weight because of which they undergo systemic distribution in body [5].…”

Section: Introductionmentioning

confidence: 99%

FITC-Dextran entrapped and silica coated gadolinium oxide nanoparticles for synchronous optical and magnetic resonance imaging applications

Kumar

Meena

Hazari

et al. 2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…7 In this regard, it is thus crucial to develop efficient nanoparticles (NPs) lacking or having minimal toxicity in vitro and in vivo, including absorption, distribution, metabolism, excretion, and immunotoxiciy. [8][9][10][11] Gd 2 O 3 is an attractive T1-weighted MRI contrast agent due to its numerous unpaired electrons, [12][13][14] but it is important to improve its biocompatibility and wettability by coating with silica. 15 These Gd-NPs are traditionally prepared by complicated two-step chemical methods using Stober chemistry.…”

Section: Introductionmentioning

confidence: 99%

Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo

Tian¹,

Yang²,

Yang³

et al. 2014

IJN

View full text Add to dashboard Cite

Poor toxicity characterization is one obstacle to the clinical deployment of Gd 2 O 3 @ SiO 2 core-shell nanoparticles (Gd-NPs) for use as magnetic resonance (MR) imaging contrast agents. To date, there is no systematic toxicity data available for Gd-NPs prepared by laser ablation in liquid. In this article, we systematically studied the Gd-NPs’ cytotoxicity, apoptosis in vitro, immunotoxicity, blood circulation half-life, biodistribution and excretion in vivo, as well as pharmacodynamics. The results show the toxicity, and in vivo MR data show that these NPs are a good contrast agent for preclinical applications. No significant differences were found in cell viability, apoptosis , and immunotoxicity between our Gd-NPs and Gd in a DTPA (diethylenetriaminepentaacetic acid) chelator. Biodistribution data reveal a greater accumulation of the Gd-NPs in the liver, spleen, lung, and tumor than in the kidney, heart, and brain. Approximately 50% of the Gd is excreted via the hepatobiliary system within 4 weeks. Furthermore, dynamic contrast-enhanced T1-weighted MR images of xenografted murine tumors were obtained after intravenous administration of the Gd-NPs. Collectively, the single step preparation of Gd-NPs by laser ablation in liquid produces particles with satisfactory cytotoxicity, minimal immunotoxicity, and efficient MR contrast. This may lead to their utility as molecular imaging contrast agents in MR imaging for cancer diagnosis.

show abstract

Synthesis route and three different core-shell impacts on magnetic characterization of gadolinium oxide-based nanoparticles as new contrast agents for molecular magnetic resonance imaging

Cited by 40 publications

References 26 publications

Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long‐Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement

Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long‐Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement

FITC-Dextran entrapped and silica coated gadolinium oxide nanoparticles for synchronous optical and magnetic resonance imaging applications

Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo

Contact Info

Product

Resources

About