Synthesis, reactions and pharmacological studies of new series of selenolo [2,3-b]tetrahydroquinoline

Abstract

A novel series of selenolo [2, 3-b] tetrahydroquinoline derivatives were synthesized by the reaction of NaSeH with 2-chloro-3-cyano-4-(4-methoxyphenyl)-5, 6, 7, 8-tetrahydroquinoline 2 followed by reactions with chloro acetone, chloro acetonitrile, ethyl chloroacetate and chloro acetamide to yield 9 and 11a-c respectively. Reactions of 11c with acetic anhydride, cyclohexanone and aromatic aldehyde affording derivatives 12-14 respectively. Spectroscopic (IR, 1HNMR, 13CNMR and MS) were confirmed the structure of the synthesized compounds. Compounds 5a-c, 9, 11a-c, 12, 13 and 14 were investigated for their anti-inflammatory and analgesic activities; in addition, the most active compounds were tested for their acute toxicity.

Synthesis, Spectroscopic Characterization and Biological Studies of Mn(II), Cu(II), Ni(II), Co(II) and Zn(II) Complexes with New Schiff Base of 2-((Pyrazine-2-ylimino)methyl)phenol

“…The median lethal dose (LD 50 ) of the most active anticancer metal complexes for HOP-62 complexes (Zn(II) and Co(II)) in addition these complexes were determined (i.p.) in mice according to reported procedures [48]. The animals got an injection (i.p.)…”

Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment

“…In the recent years, selenium compounds have gained substantial interest not only for their importance in synthetic chemistry but also for their biological properties (Burling and Goldstein, 1992 ; Lobinski et al, 2000 ; Koketsu et al, 2002 ; Abdel-Hafez, 2008 ; Potewar et al, 2008 ; Abdel-Lattif et al, 2014 ; Al-Rubaie et al, 2014 ). Furthermore, the incorporation of selenium functionalities into organic scaffolds reported to permit alteration of their chemical and biological activities (Al-Smadi and Al-Momani, 2008 ).…”