Synthesis, antileishmanial and cytotoxicity activities of fused and nonfused tetrahydroquinoline derivatives

Madkour, H. M. F.; El‐Hashash, M. A.; Salem, Marwa S.; Mahmoud, Al-Shimaa Omar Ali

doi:10.1007/s11164-018-3311-6

Cited by 12 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, a library of 2-amino-5,6,7,8-tetrahydroquinolines 1470 , potential precursors for the synthesis of biologically relevant heterocyclic compounds, were prepared in one pot from cyclic ketone 1467 , aldehydes 1468 , malononitrile 1469 , and ammonium acetate in good yields (Scheme ). − In addition, similar transformations were achieved starting from ethyl cyanoacetate or cyanoacetamide …”

Section: Synthesis Of Tetrahydroquinolines With Other Hydrogenation P...mentioning

confidence: 99%

“…58−60 In addition, similar transformations were achieved starting from ethyl cyanoacetate or cyanoacetamide. 618 3-Cyano-5,6,7,8-tetrahydroquinoline derivatives are also accessible via an ANRORC-type oxygen−nitrogen exchange, by treatment of the corresponding 5,6,7,8-tetrahydrobenzopyran derivatives with ammonium acetate in refluxing DMSO. 619 Scheme 394.…”

Section: Synthesis Of Tetrahydroquinolines Withmentioning

confidence: 99%

See 1 more Smart Citation

Progress in the Chemistry of Tetrahydroquinolines

2019

View full text Add to dashboard Cite

show abstract

Section: Synthesis Of Tetrahydroquinolines With Other Hydrogenation P...mentioning

confidence: 99%

Section: Synthesis Of Tetrahydroquinolines Withmentioning

confidence: 99%

Progress in the Chemistry of Tetrahydroquinolines

2019

View full text Add to dashboard Cite

show abstract

“…In continuation of our previous work, [ 24–29 ] the present work aimed at utilization of 3‐hydroxy‐6‐iodo‐2‐phenylquniazolin‐4(3 H )‐one ( 1 ) for synthesis of different heterocyclic compounds and evaluate them as anticancer agents. Hydroxyquinazolinone 1 was synthesized in our laboratory according to one of our previous publication.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and antiproliferative evaluation of some novel quinazolin‐4(3H)‐one derivatives

Salem

Al‐Mabrook

El‐Hashash

2020

Journal of Heterocyclic Chem

Self Cite

View full text Add to dashboard Cite

A series of novel quinazolinone derivatives was designed and synthesized. The antiproliferative activities were evaluated in vitro using MTT assay against hepatocellular carcinoma (HepG‐2) and mammary gland breast cancer (MCF‐7). The preliminary bioassay results demonstrated that tested compounds exhibited antiproliferation with various degrees. Triazole moiety enhanced the activity against the two cell lines when incorporating with quinazolinone moiety in a single molecular framework. Acetohydrazide‐quinazolinone derivative showed strong activity against the two cancer cells comparable to that of doxorubicin. Biological evaluation indicated that all the tested compounds possessed antiproliferative activity with certain degrees.

show abstract

“…In continuation of our previous work, the present work aims at utilization of the reactivity of 2‐thioxo‐1,2‐dihydrobenzo[d][1,3]thiazin‐4‐one ( 1 ) toward different electrophilic and nucleophilic reagents to design and construct new fused and nonfused heterocyclic systems and evaluate them for antitumor activity.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and cytotoxic activity against human tumor cells of heterocyclic systems derived from 2‐thioxo‐1,2‐dihydro‐4H‐3,1‐benzothazin‐4‐one

Khlosy

Salem

Ali

et al. 2019

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

The title compound was prepared and converted to 2-hydrazinyl-1,2-dihydro-4H-benzo[d] [1,3]thiazin-4-one which was utilized to synthesize fused heterocyclic systems, namely benzotriazolothiazinone derivatives, as well as, nonfused heterocyclic systems such as pyrazolyl-benzothiazinones, benzothiazinylpyridazine and imidazolylbenzothiazinone derivatives via reaction with formamide, acetic acid, ethyl cyanoacetate, maleic anhydride and benzaldehyde followed by treatment with glycine, respectively. All compounds have been structurally characterized by means of IR, MS, and 1 H-NMR spectra. The synthesized compounds were evaluated in vitro for their antiproliferative activity against HePG-2 and MCF-7 cell lines. 2H-Benzo[d][1,3]thiazine-2,4 (1H)-dithione and 2-thioxo-1,2-dihydro-4H-benzo[d] [1,3]thiazin-4-one were the most potent against the two cancer cells compared to that of the reference compound doxorubicin. Most of the synthesized compounds also exhibited good cytotoxic activity.

show abstract

Synthesis, antileishmanial and cytotoxicity activities of fused and nonfused tetrahydroquinoline derivatives

Cited by 12 publications

References 26 publications

Progress in the Chemistry of Tetrahydroquinolines

Progress in the Chemistry of Tetrahydroquinolines

Synthesis and antiproliferative evaluation of some novel quinazolin‐4(3H)‐one derivatives

Synthesis and cytotoxic activity against human tumor cells of heterocyclic systems derived from 2‐thioxo‐1,2‐dihydro‐4H‐3,1‐benzothazin‐4‐one

Contact Info

Product

Resources

About