Synthesis, Reactions, and Pharmacological Screening of Heterocyclic Derivatives Using Nicotinic Acid as a Natural Synthon.

Abstract

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Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties

“…Diverse applications of 2-thioxoimidazolidin-4-one in drug field have encouraged the medicinal chemists to synthesize and evaluate a large number of novel molecules. In this research point, we design new compounds based on the biological activity of other heterocycles such as pyrazoles [ 18 , 19 ], triazoles [ 20 , 21 ], benzimidazole [ 22 ], benzoxazole [ 23 ] and Schiff bases [ 24 – 26 ] in the field of cancer and microbial therapy. As an extension of our work on the synthesis of heterocyclic systems and evaluation of their biological activity [ 27 – 33 ], we reported here the synthesis of some novel substituted 2-thiohydantoin and evaluate their cytotoxic activity.…”

Effect of Ni doping on structural, optical and photocatalytic properties of Zn1-XNiXO nanoparticles prepared by different pH conditions

“…The α,β-enone moiety of the molecule is a favorable unit for dipolar cycloaddition with numerous reagents providing heterocyclic compounds of different ring sizes with one or several heteroatoms. Their reactions with dinucleophiles usually result in the formation of polycyclic ring systems which may be the skeleton of important heterocyclic compounds [1][2][3][4][5]. Moreover, dihydropyrimidinones 1 (DHPMs, Biginelli compounds) appear to be a class of privileged organic compounds with medicinal significance due to their different biological and therapeutic activities [6].…”

Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives

“…Chalcones are synthesized by condensing ketones with aromatic aldehydes in the presence of suitable bases. They are very useful intermediates for the synthesis of five- [ 1 , 2 ], six- [ 1 , 3 ] and seven-membered [ 4 ] heterocyclic compounds. Chalcone derivatives exhibit diverse pharmacological activities [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”