Synthesis, radical scavenging, and antioxidant activity of stilbazolic resveratrol analogs

Semenov, A.; Balakireva, Olga I.; Tarasova, I. V.; Семенова, Е. В.; Zul'fugarov, P. K.

doi:10.1007/s00044-020-02585-6

Cited by 7 publications

(1 citation statement)

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“…Resveratrol is a naturally occurring polyphenolic antioxidant, belonging to the stilbene family, produced by the plants in response to a microbial attack. The antibacterial activity of RSV has been described, based on more than a single mechanism, such as alteration of the lipid bilayer of the membrane and its permeability, changes in intracellular functions induced by hydrogen bonding of the phenolic group in 4-position to enzymes, and antioxidant-scavenging activity that could inhibit the generation of reactive oxygen species, reducing the redox potential of the growth medium [ 41 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Searching for New Tools to Counteract the Helicobacter pylori Resistance: The Positive Action of Resveratrol Derivatives

et al. 2020

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The drug-resistance phenomenon in Helicobacter pylori underlines the need of novel strategies to improve the eradication rate including alternative treatments combining antibiotic and non-antibiotic compounds with synergistic action. In this study, the antibacterial (MIC/MBC) and anti-virulence effects (biofilm reduction and swarming motility inhibition) of resveratrol-RSV and new synthetized RSV-phenol derivatives, with a higher bioavailability, alone and combined with levofloxacin-LVX were evaluated against resistant H. pylori clinical strains. The experiments were confirmed in vivo using the Galleria mellonella model. Among the studied RSV derivatives, RSV-3 and RSV-4 possessed higher antibacterial activity with respect to RSV (MICs from 6.25 to 200 µg/mL and from 3.12 to 200 µg/mL, respectively). RSV, RSV-3, and RSV-4 were able to synergize with LVX restoring its effect in two out of seven clinical resistant strains tested for the study. RSV, RSV-3, and RSV-4, alone and with LVX at sub-MIC and sub-synergistic concentrations, significantly reduced the biofilm formation. Moreover, RSV-3 and RSV-4 reduced the H. pylori swarming motility on soft agar. RSV, RSV-3, and RSV-4 were non-toxic for G. mellonella larvae and displayed a protective effect against H. pylori infection. Overall, RSV–phenol derivatives should be considered interesting candidates for innovative therapeutic schemes to tackle the H. pylori antibiotic resistance.

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Section: Discussionmentioning

confidence: 99%