Synthesis, preparation, in vitro degradation, and application of novel degradable bioelastomers—A review

Liu, Quanyong; Jiang, Lei; Shi, Rui; Zhang, Liqun

doi:10.1016/j.progpolymsci.2011.11.001

Cited by 183 publications

(114 citation statements)

References 250 publications

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“…Among natural materials the collagen, chitosan and chitin, glucosamine and demineralized bone were proposed [9,10]. Among synthetic biodegradable polymers, PGA (polyglycolide, poly (glycolic acid)), PLA (polylactide, poly (lactic acid)), PLGA (polylactic acid polymer and glycolic acid), PLLA (poly-L -lactic acid), polyanhydrides, polifumarates, polyorthoesters, polycarbonates, polycaprolactones and some others have been investigated and applied [9,10,11]. Natural polymers promote better adhesion and cell functions, but may show genotoxicity and contain patogens.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

“…Collagen is a natural component of an extracellular matrix (ECM) and the most often proposed biodegradable natural polymer. Its advantage is due to its positive impact on the formation of vascularised tissue [11]. Moreover, it can appear in a form of hydrogel, makes it possible to introduce growth factors promoting angiogenesis, such as VEGF -vascular endothelial growth factor.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

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Bioactive core material for porous load-bearing implants

Sobieszczyk¹,

Melaniuk²,

Zieliński³

2012

Advances in Materials Sciences

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So far state of knowledge on biodegradable materials is reviewed. Among a variety of investigated materials, those composed of polymers and ceramics may be considered as only candidates for a core material in porous titanium alloy. The collagen and chitosan among natural polymers, polyhydroxy acids among synthetic polymers, and hydroxyapatite and tricalcium phosphate among ceramics are proposed for further research. Three essential conditions for a core material are defined as: biodegradation rate "in vitro" and "in vivo" close to bone tissue in-growth rate, high compression strength and ability to form nanoporous open structure inside the material for vascularisation. Possible deposition techniques of a core material within the macropores of metallic scaffold include infiltration of titanium porous structure with polymer scaffold followed by precipitation of phosphate nanoparticles, and mixing of phosphate and polymers before deposition followed by controlled precipitation inside the pores.

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Section: Biodegradable Polymersmentioning

confidence: 99%

Section: Biodegradable Polymersmentioning

confidence: 99%

Bioactive core material for porous load-bearing implants

Sobieszczyk¹,

Melaniuk²,

Zieliński³

2012

Advances in Materials Sciences

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“…Huayu Tian et al 14 prepared synthetic biodegradable polymers which are widely used in biomedical fields and they are found to be bioactive and biocompatible. Peng Xue et al 15 16,17 . The objective of the present work is to synthesize the aliphatic copolyesters from sebacic acid / adipic acid, PEG400 as a common monomer with 1, 8-octanediol / 1, 12-dodecanediol by melt polycondensation technique in the presence of Ti (IV) isopropoxide as a catalyst.…”

Section: Introductionmentioning

confidence: 99%

"Synthesis, Characterization and Comparison of Biodegradable Aliphatic Copolyesters: Poly Ethylene Glycol Octanediol Sebacate and Polyethylene Glycol Dodecanediol Adipate"

2018

RJC

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Biodegradable random aliphatic copolymers were synthesized through melt polycondensation with titanium tetraisopropoxide Ti(ipo)4 as a catalyst to produce polyethylene glycol octanediol sebacate (PEOSEB) and polyethylene glycol dodecanediol adipate (PEDDAD). The prepared copolymers were characterized by Fourier transform vibrational spectroscopy(FTIR), Nuclear magnetic resonance (NMR), Differential scanning calorimetry (DSC), Thermo gravimetric analysis (TGA) and Wide angle x-ray diffraction studies (WAXD). The viscosity measurements were studied using ubbelholde viscometer. Both the copolymers possessed antibacterial and antifungal properties. We have also reported the antioxidant behavior of these copolymers by DPPH method and hydrolytic degradation studies by phosphate buffer method.

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“…Also some other properties of them such as stable 3D network, adjustable drug release, elasticity and flexibility together with good mechanical characteristics are favorable in drug delivery systems [37]. It is proved that cross-linked polymers are normally stable so during degradation, they are able to protect their dimensions for longer time.…”

Section: Introductionmentioning

confidence: 99%