Synthesis, physico-chemical properties, and antimicrobial evaluation of a new series of iron(III) hexadentate chelators

Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: Design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains

“…All the hexadentate chelators were fully characterized by 1 H NMR, 13 C NMR, mass spectrometry and highresolution mass spectrometry. In comparison with our previously reported hexadentate HPOs [17,18,25], structures of the hexadentate HPOs synthesized in this article could be changed by introducing different substituents on the side chain and position-1 on pyridinone ring. Thus, a large number of hexadentate HPO analogues possessing different partition coefficients can be prepared, which is useful in the establishment of a structureeactivity relationship.…”

Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

“…A significant number of reports have also described growth inhibition of a range of pathogenic bacteria by bidentate or hexadentate chelators based upon 3.4-HOPO [34][35][36][37][38][39][40][41][42][43]. To achieve high pFe 3+ , hexadentate chelators are preferred to bidentate ones, especially since their mode of action as biostatic agents is expected to be extracellular and therefore do not suffer from size restriction to penetrate the microbes.…”

In vitroantimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin

“…Thus, desferrioxamine increases the virulence of some microorganisms, such as Yersinia and Klebsiella, because it is hydroxamate-based siderophore (Denicola et al, 1995), the microorganisms are able to utilize the iron complex (Collins et al, 2002;Chan et al, 2009). However, we have previously demonstrated that 3-hydroxypyridin-4-ones, which have a different iron-binding moiety to those of siderophores, inhibit the growth of both Gram-positive and Gram-negative bacteria Xu et al, 2011;Xie et al, 2013).…”