No abstract

A novel 3-hydroxypyridin-4-one (HPO) hexadentate monomeric chelator 14 has been synthesized and incorporated into polymers by copolymerization with 2-hydroxyethyl acrylate (HEA), using azobisisobutyronitrile (AIBN) as an initiator. The monomeric chelator was found to possess very high affinity for iron(III), with a log stability constant of iron complex (logK1)=33.61 and pFe 3+ =30.37. The iron binding capacity and monomer recovery of the copolymers was determined using spectrophotometry. In vitro antimicrobial activity of the monomeric chelator 14 and polymeric chelator 16-4 against both Gram-positive bacteria (Staphyloccocus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Salmonella spp., Pseudomonas aeruginosa) was evaluated by inhibition zone and minimum inhibitory concentration (MIC) assays, which demonstrated that both monomeric and polymeric chelators possess inhibitory activity. The polymeric chelators possess potential application for the treatment of wound infection.