Synthesis, Phosphonylation, and Anti-Viral Activity of Some 6-Aryl-5-cyano-2-thiouracils

Pyrimidines as Anticancer and Antiviral: Synthesis & Reactions (A Review)

“…Recently, A.A. Babushkina and coauthors reported 79 the synthesis and anti-influenza A virus (H1N1) of 6-aryl-5-cyano-2-thiouracil (112) via one pot three components addition of thiourea, ethyl cyanoacetate and aldehydes. The products were undergone phosphonylation by the reaction with diethyl chloroethynylphosphonate to afford 113 (Scheme 47).…”

Synthesis, recyclization under the action of methanol and analgetic activity of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides

“…Previously, we proposed a simple method for the preparation of 3-hydrazinylidenefuran-2(3H)-one derivatives by intramolecular cyclization of substituted 2-[2-(4-Rbenzoyl)hydrazinylidene]-4-oxobutanoic acids in the presence of acetic or propionic anhydride [35,36]. Furthermore, this method was applied to 3-imino(thiophen-2-yl)furan-2(3H)-ones derivatives, which include the pharmacophore fragment, Gewald aminothiophene [37][38][39][40][41]. Compounds that contain this pharmacophore fragment exhibit analgesic [42][43][44], anti-inflammatory [45,46], antimicrobial [47][48][49] and photoluminescent properties [50,51] and other biological activities [52][53][54].…”

Synthesis and Evaluation of The Antiviral Activity of Novel 2-Thiopyrimidine-5-Carbonitrile Derivatives

“…Some studies indicated that 2-thiouracil has an inhibitory effect on the growth of some culture viruses [4,5], but this inhibitory effect is very limited against animal viruses such as inhibiting the growth of vaccinia virus in tissue culture [6] as well as its ability to disable poliovirus [7]. In this context, we have focused in this research on thiouracil compounds due to diversity of their biological activity as antibacterial [8][9][10][11], antifungal [12][13][14], anticancer [15][16][17][18], antioxidant [19,20], antiviral [21][22][23], antithyroid [24,25]…etc. agents.…”