“…As shown in Figure 1, the cavity diameter is 6.4 À, which contributes to the interaction with guest molecules [39]. As a functional modifier, β-CD has been used for the SERS detection of both organic pollutants and inorganic ions, such as polychlorinated biphenyls (PCB-77, PCB-1) down to 3 μM, [40] methyl parathion at picomolar level, [41] PAHs (anthracene, pyrene or anthrecene) [39,42] and micromolar Pb 2+ ions [29]. In most of the reported works, thio-modified β-CD (such as per-6-deoxy-(6-thio)-β-CD) was used because of the weak modifying efficiency of natural β-CD onto the surface of the metal structure.…”