Synthesis of α-chloroacetophenones with NH4Cl/Oxone® in situ followed by bioreduction with whole cells of marine-derived fungi

Morais, Aline T.do B.; Ferreira, Irlon M.; Jimenez, David Esteban Quintero; Porto, André Luiz Meleiro

doi:10.1016/j.bcab.2018.08.003

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…= 12–97%, phosphate buffer pH 7.0, 32°C, 130 rpm, 6 days). It is important to note that the biocatalytic reactions were carried out after the filtration of the ozone salt and methanol removal by rotoevaporation, thus without purification of the intermediate in a greener methodology (Morais et al, 2018). It is noteworthy that these studies reported different advances in the use of marine-derived fungi as biocatalysts, generating cleaner, easier, and cost-reduced processes.…”

Section: Whole-cell Processesmentioning

confidence: 99%

Applications of Marine-Derived Microorganisms and Their Enzymes in Biocatalysis and Biotransformation, the Underexplored Potentials

2019

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Biodiversity has been explored in the search for novel enzymes, including forests, savannas, tundras, deserts, and finally the sea. Marine microorganisms and their enzymes are capable of being active in high-salt concentration, large range of temperature, and high incidence of light and pressure, constituting an important source of unique biocatalysts. This review presents studies employing whole-cell processes of marine bacteria and fungi, aiming for new catalysts for different reactions in organic synthesis, such as reduction, oxidation, hydroxylation, hydrolysis, elimination, and conjugation. Genomics and protein engineering studies were also approached, and reactions employing isolated enzymes from different classes (oxidoreductases, hydrolases, lyases, and ligases) were described and summarized. Future biotechnological studies and process development should focus on molecular biology for the obtention of enzymes with interesting, fascinating and enhanced properties, starting from the exploration of microorganisms from the marine environment. This review approaches the literature about the use of marine-derived bacteria, fungi, and their enzymes for biocatalytic reactions of organic compounds, promoting a discussion about the possibilities of these microorganisms in the synthesis of different substances.

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Section: Whole-cell Processesmentioning

confidence: 99%

Applications of Marine-Derived Microorganisms and Their Enzymes in Biocatalysis and Biotransformation, the Underexplored Potentials

2019

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“…Also, Jimenez et al reported that A. sydowii CBMAI 935 associated with C. erecta sponge collected from Sao Sebastiao, São Paulo, Brazil, enantioselectively reduced ene of E-2-cyano-3-(furan-2-yl)acrylamide to (R)-2-cyano-3-(furan-2-yl)propanamide with a high yield [ 125 ]. In 2018, Morais et al studied the reduction of α-chloroacetophenones to (S)-alcohols using whole cells of marine-derived A. sydowii CBMAI 935 [ 126 ]. α-bromoacetophenones‘ biotransformation by the marine-derived A. sydowii Ce19 was studied by Rocha et al in 2010 [ 127 ].…”

Section: Industrial and Biotechnological Applicationsmentioning

confidence: 99%

Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

Ibrahim,

Mohamed,

Alsaadi

et al. 2023

Marine Drugs

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Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical, and agricultural fields. Aspergillus sydowii is a saprotrophic, ubiquitous, and halophilic fungus that is commonly found in different marine ecosystems. This fungus can cause aspergillosis in sea fan corals leading to sea fan mortality with subsequent changes in coral community structure. Interestingly, A. sydowi is a prolific source of distinct and structurally varied metabolites such as alkaloids, xanthones, terpenes, anthraquinones, sterols, diphenyl ethers, pyrones, cyclopentenones, and polyketides with a range of bioactivities. A. sydowii has capacity to produce various enzymes with marked industrial and biotechnological potential, including α-amylases, lipases, xylanases, cellulases, keratinases, and tannases. Also, this fungus has the capacity for bioremediation as well as the biocatalysis of various chemical reactions. The current work aimed at focusing on the bright side of this fungus. In this review, published studies on isolated metabolites from A. sydowii, including their structures, biological functions, and biosynthesis, as well as the biotechnological and industrial significance of this fungus, were highlighted. More than 245 compounds were described in the current review with 134 references published within the period from 1975 to June 2023.

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“…Marine fungi were isolated from the sponges G. corticostylifera and C. erecta, collected off the coast at São Sebastião in the north of the state of São Paulo, Brazil. Morais et al (2018) reported the chemical synthesis of α-chloroketones, in situ, followed by reduction with whole cells of marine-derived fungi. P. citrinum CBMAI 1186, P. oxalicum CBMAI 1185, A. sydowii CBMAI 935, P. raistrickii CBMAI 931 and M. racemosus CBMAI 847 were used for the reduction of α-chloroacetophenones rendering (S)-alcohols.…”

Section: Biotransformation Of Carbonyl Compoundsmentioning

confidence: 99%

Marine-derived fungi as biocatalysts

Virués-Segovia

Muñoz-Mira²,

Durán-Patrón³

et al. 2023

Front. Microbiol.

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Marine microorganisms account for over 90% of ocean biomass and their diversity is believed to be the result of their ability to adapt to extreme conditions of the marine environment. Biotransformations are used to produce a wide range of high-added value materials, and marine-derived fungi have proven to be a source of new enzymes, even for activities not previously discovered. This review focuses on biotransformations by fungi from marine environments, including bioremediation, from the standpoint of the chemical structure of the substrate, and covers up to September 2022.

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Synthesis of α-chloroacetophenones with NH4Cl/Oxone® in situ followed by bioreduction with whole cells of marine-derived fungi

Cited by 7 publications

References 30 publications

Applications of Marine-Derived Microorganisms and Their Enzymes in Biocatalysis and Biotransformation, the Underexplored Potentials

Applications of Marine-Derived Microorganisms and Their Enzymes in Biocatalysis and Biotransformation, the Underexplored Potentials

Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

Marine-derived fungi as biocatalysts

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