Synthesis of transition metal isocyanide complexes containing hydrogen bonding sites in peripheral locations

Lau, Ka Yin; Mayr, Andreas; Cheung, Kung‐Kai

doi:10.1016/s0020-1693(98)00352-1

Cited by 91 publications

(62 citation statements)

References 102 publications

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“…accordance with the fact that chelation increases the activity. e chelation reduces the polarity [24,25] of the metal ion, mainly, because of the partial sharing of its positive charge with the donor groups and possibly the -electron delocalization within the whole chelate ring [26][27][28]. is process of chelation thus increases the lipophilic nature of the central metal atom, which in turn favours its permeation through the lipid layer of the membrane [29][30][31].…”

Section: 3mentioning

confidence: 99%

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Gupta

Sihag

Varshney

et al. 2013

Journal of Chemistry

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Some new coordination compounds of palladium(II) have been synthesized by the reaction of palladium(II) acetate with azomethines in a 1 : 2 molar ratio using acetonitrile as a reaction medium. Azomethines used in these studies have been prepared by the condensation of 2-acetyl �uorene and 4-acetyl biphenyl with glycine, alanine, valine, and leucine in methanol. An attempt has been made to probe their bonding and structures on the basis of elemental analyses and IR, 1 H, and 13 C NMR spectral studies. Pd(II) compounds have been found to be more active than their uncomplexed ligands as both of them were screened for antibacterial, antifungal, and insecticidal activities.

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Section: 3mentioning

confidence: 99%

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Gupta

Sihag

Varshney

et al. 2013

Journal of Chemistry

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“…Various cobalt, nickel and copper metal complexes were reported to have antimicrobial activities (El-Ayaan and Abdel-Aziz, 2005;Sonmez et al, 2006). Schiff bases are characterized by the −N=CH− (imine) group which is important for elucidating the mechanism of transamination and racemisation reactions in biological systems (Lau et al, 1999) and are also known to have biological activities such as antimicrobial (Fioravanti et al, 1995;El-Masry et al, 2000;Pandeya et al, 1999), antifungal (Singh and Dash, 1998), antitumor (Desai et al, 2001) and herbicidal (Samadhiya and Halve, 2001). Schiff bases continue to occupy an important position as ligands in metal coordination chemistry (Wu et al, 2004;Aydogan et al, 2001), even almost a century since their discovery.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2′-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents

Azam

Singh

Khokhra

et al. 2007

J. Zhejiang Univ. - Sci. B

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Abstract:Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipophilic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthesized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)benzylideneaminonaphthothiazole was converted to its Co(II), Ni(II) and Cu(II) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bacteria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Gram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(II) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases.

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“…Infrared spectra (KBr, 4000-400 cm -1 ) have been recorded on AVATAR-300 Fourier transform spectrophotometer. Instrum AV300 NMR spectrometer was used for recording NMR spectra operating 500 MHz for recording 1 [64] were prepared by the procedure published in literature.…”

Section: Methodsmentioning

confidence: 99%

“…Schiff bases are bimolecular condensation products of primary amines with carbonyl compounds. Schiff bases are characterized by the -N=CH-(imine) group which finds importance in elucidating the mechanism of transamination and racemization reactions in biological systems [1,2]. Schiff bases of aliphatic aldehydes are relatively unstable which readily undergo polymerization while those of aromatic aldehydes having an effective conjugation system are found to be more stable.…”

Section: Introductionmentioning

confidence: 99%

Solvent-Free Synthesis and Spectral Linearity of Some (E)-2-(substituted benzylideneamino)-N-(3-chloro-4-fluorophenyl)-hexahydro-2<i>H</i>-cyclopenta[b]thiophene-3-carboxamides

Thirunarayanan

Sekar²

2013

ILCPA

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Some(E)-2-(substituted benzylideneamino)-N-(3-chloro-4-fluorophenyl)-hexahydro-2H-cyclopenta [b]thiophene-3-carboxamide derivatives have been synthesized by SiO 2 :H 3 PO 4 catalyzed solventfree condensation of 2-amino-N-(3-chloro-4-fluorophenyl)-hexahydro-2H-cyclopenta [b]thiophene-3-carboxamide and various substituted benzaldehydes in microwave irradiation. The yield of the iminecarboximido derivatives has been found to be more than 85 %. The purity of all imine-carboximido derivatives has been checked using their physical constants and spectral data. The spectral data of the iminecarboximido derivatives such as infrared ν (cm -1 ) of CO, NH, C-N, C-Cl, C-F, C=N, and the NMR chemical shifts (δ, ppm) of NH, CH, CO and C=N have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis, the effects of substituent on the above spectral group absorptions have been discussed.

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Synthesis of transition metal isocyanide complexes containing hydrogen bonding sites in peripheral locations

Cited by 91 publications

References 102 publications

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Synthesis, Structural, and Antimicrobial Studies of Some New Coordination Compounds of Palladium(II) with Azomethines Derived from Amino Acids

Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2′-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents

Solvent-Free Synthesis and Spectral Linearity of Some (E)-2-(substituted benzylideneamino)-N-(3-chloro-4-fluorophenyl)-hexahydro-2<i>H</i>-cyclopenta[b]thiophene-3-carboxamides

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