Synthesis of Thioethers Using Triethylamine-Activated Phosphorus Decasulfide (P4S10)

Abstract

X Br P 4 S 10 X S X R R R X: C=O, none 8 examples up to 99% yield Et 3 N, Et 2 O rt, 1-20 h S O Br P 4 S 10

Multicomponent Solvent-Free Synthesis, Antibacterial Evaluation and QSAR Study of 2-(Bis(benzylthio)methylene) malononitriles

“…8 New methods and procedures were developed to synthesize organic sulfides. For this purpose, metal-catalyzed reactions, [9][10][11] Sandmeyer and Leuckart reactions, 12,13 coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide, 14 photocatalytically initiated thiol-ene reaction, 15 free radical displacement on alkynes, 16 regioselective conjugate addition of thiols to acyclic α,β,γ,δ-unsaturated dienones, 17 in situ nucleophilic substitution of aryl bromides with potassium iodomethyltrifluoroborates, 18 displacement reaction of halogens by sulfur, 19 Stevens rearrangement of thioethers with arynes, 20 and synthesis of thiiranes via reaction of epoxides with thiourea in DES 21 were proposed by researchers. Alkylation of thiols or their salts is a well-developed method for the preparation of thioether derivatives.…”