Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors

Membrane surface functionalization via theophylline derivative coating and streptavidin immobilization

“…3(b)), theophylline signals can be clearly seen and do fit the lines for the theophylline derivative Theo1. By comparison with the reported data [18], picks at 158. from PVDF (-CF 2 -and -CH 2 -resonances, respectively) [28,29], and they are also broad which typical for NMR in solids. Impedance spectroscopy plots also confirm the presence of Theo1 in the surfaces of both modified membranes as well as in the structure of the swollen RC support.…”

“…The biological effect of theophyllines is associated to its affinity with a family of adenosine receptors known as A 1 , A 2A , A 2B , and A 3 [16]. Recently, several 1,3-dialkyl deazaxanthines as well as several theophylline-oligo(ethylene glycol) based anchors have been reported as potent A 2B adenosine receptor antagonists [17,18]. In particular, the oligo(ethylene glycol)-alkene theophylline substituted (Theo1, Fig.…”

Recent Synthetic Approaches Towards Biologically Potent Derivatives/Analogues of Theophylline

“…Keeping in consideration the above mentioned study, Hierrezuelo et al . in 2010 presented the synthesis of several theophylline‐oligo(ethylene glycol) based props. Also, they proposed the synthesis of few compounds that showed activities on adenosine receptors and hence were tested on silicon substrate region.…”

Synthesis and hypoglycemic activity of some new theophylline derivatives

“…The fact that substituted theophylline derivatives exerted interesting biological activities [12][13][14][15][16] promoted us to prepare the 7-acetohydrazide derivative 3 by hydrazinolysis of the ethyl acetate ester derivative 2.…”