Synthesis of tertiary amine polymers

Danusso, F.; Ferruti, Paolo

doi:10.1016/0032-3861(70)90029-7

Cited by 160 publications

(111 citation statements)

References 15 publications

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“…The two polymer classes chosen, both featuring linear polyamide-type main chains, were (1) polyaspartamides derived from polysuccinimide by nucleophilic ring-opening steps, and (2) polyamidoamines obtained by Michael addition polymerization of bisacrylamides with primary and/or secondary amine comonomers. The polyaspartamides were pioneered in the 'Seventies by Neri and Antoni [54,55] and others [56][57][58], whereas Ferruti's laboratory [59,60] initiated and promoted work on the polyamidoamines. Subsequently, the two carrier classes were further developed by our group [61,62].…”

Section: Resultsmentioning

confidence: 99%

Macromolecular Antiproliferative Agents Featuring Dicarboxylato-Chelated Platinum

Komane

Mukaya

Neuse

et al. 2007

J Inorg Organomet Polym

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Cancerous diseases, together with cardiac afflictions, account for the predominant causes of death among the adult population of the Western world. The classical platinum drugs, with cisplatin as their parent, have established themselves for years as leading components in the oncologist's arsenal of antitumor agents. As with most other antineoplastic drugs, however, incisive pharmacological deficiencies, notably excessive systemic toxicity and induction of drug resistance, have severely curtailed their overall efficaciousness. With the objective of overcoming these counterproductive deficiencies, the technique of polymer-drug conjugation, representing an advanced modality of drug delivery, has been developed in recent years to high standards worldwide. In a drug conjugate, water-soluble macromolecular carrier constructs designed in compliance with stringent pharmacological specifications are covalently, yet bioreversibly, interconnected with the bioactive agent. As a macromolecule following a pharmacokinetic pathway different from that of non-polymeric compounds, the conjugate acts as a pro-drug favorably transporting the agent through the various body compartments to, and into, the target cell, where the agent is enzymatically or hydrolytically separated from the carrier for its biological action. In the authors' laboratories the conjugation strategy has been adopted as the primary tool for drug efficacy enhancement. The present paper describes a special type of platinum complex carrier-bound via dicarboxymetal chelation, synthesized from carboxyl-functionalized polyamide-type carriers by platination with trans-1,2-diaminocyclohexanediaquaplatinum(II) dinitrate. In a series of in vitro tests antiproliferative activities have been determined against several human cancer cell lines. Whereas no improvements are observed in tests against a colorectal cancer, outstanding findings of the screening program include a 10-to 100-fold increase in cell-killing performance of the conjugates relative to the (non-polymeric) cisplatin standard against the HeLa adenocarcinoma, and distinctly reduced resistance factors (again, relative to cisplatin) in tests against the A2780 and A2780-cis pair of ovarian cell lines. These findings augur well for future developments of this class of platinum drugs. This article is dedicated to Professor Astruc.

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Section: Resultsmentioning

confidence: 99%

Macromolecular Antiproliferative Agents Featuring Dicarboxylato-Chelated Platinum

Komane

Mukaya

Neuse

et al. 2007

J Inorg Organomet Polym

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“…Poly(amidoamines)s (PAAs) are a family of biodegradable and biocompatible polymers whose synthesis was reported more than 40 years ago [32] and since then they have been used in different fields [33], among which biomedical applications are prominent [34]. The preparation process of PAAs is simple, environmentally friendly and easily scalable, thus being suitable to be commercialized in regions characterized by low per capita income.…”

Section: Poly(amidoamine)smentioning

confidence: 99%

Polyamidoamine Nanoparticles as Nanocarriers for the Drug Delivery to Malaria Parasite Stages in the Mosquito Vector

Urbán

Ranucci

Fernàndez‐Busquets

2015

Nanomedicine (Lond.)

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SummaryMalaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the protist Plasmodium spp. With the advent of nanoscience, renewed hopes have appeared of finally obtaining the long sought-after magic bullet against malaria in the form of a nanovector for the targeted delivery of antimalarial compounds exclusively to Plasmodium-infected cells, thus increasing drug efficacy and minimizing the induction of resistance to newly developed therapeutic agents. Poly(amidoamine) (PAA)-derived nanovectors combine into a single chemical structure drug encapsulating capacity, antimalarial activity, low unspecific toxicity, specific targeting to Plasmodium, optimal in vivo activity, and affordable synthesis cost. After having shown their efficacy in targeting drugs to intraerythrocytic parasites, now PAAs face the challenge of spearheading a new generation of nanocarriers aiming at the malaria parasite stages in the mosquito vector.

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“…This note reports the successful synthesis of polysulfone-amines with inherent viscosities as high as 1.6 dL/g from combinations of divinyl sulfone and four piperazines [eqs. (1) and (2)]:…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polysulfone‐amines by polyaddition of piperazines to divinyl sulfone

Imai

Shimizu

Sato

et al. 1981

J. Polym. Sci. Polym. Chem. Ed.

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Synthesis of tertiary amine polymers

Cited by 160 publications

References 15 publications

Macromolecular Antiproliferative Agents Featuring Dicarboxylato-Chelated Platinum

Macromolecular Antiproliferative Agents Featuring Dicarboxylato-Chelated Platinum

Polyamidoamine Nanoparticles as Nanocarriers for the Drug Delivery to Malaria Parasite Stages in the Mosquito Vector

Synthesis of polysulfone‐amines by polyaddition of piperazines to divinyl sulfone

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