Synthesis of Superparamagnetic Nanotubes as MRI Contrast Agents and for Cell Labeling

Bai, Xia; Son, Sang Jun; Zhang, Shixiong; Liu, Wei; Jordan, Elaine; Frank, Joseph A.; Venkatesan, T.; Lee, Sang Bok

doi:10.2217/17435889.3.2.163

Cited by 53 publications

(43 citation statements)

References 49 publications

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“…Magnetic resonance imaging (MRI) with its excellent spatial resolution and ability to depict tissues well regardless of depth has been recognized as one of the best noninvasive imaging methods in both clinical and research fields. Cell tracking based on MRI has been extensively studied over the past decade [8][9][10][11][12], and labeling and tracking of stem cells by MRI has also attracted much attention in the investigation of cell-tissue interactions and for guiding effective stem cell therapies [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable magnetic-fluorescent magnetite/poly(dl-lactic acid-co-α,β-malic acid) composite nanoparticles for stem cell labeling

Wang¹,

Neoh²,

Kang³

et al. 2010

Biomaterials

109

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Section: Introductionmentioning

confidence: 99%

Biodegradable magnetic-fluorescent magnetite/poly(dl-lactic acid-co-α,β-malic acid) composite nanoparticles for stem cell labeling

Wang¹,

Neoh²,

Kang³

et al. 2010

Biomaterials

109

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“…Due to their tubular structure and magnetism, magnetic nanotubes are among the most promising candidates for multifunctional nanomaterials in diagnostic and therapeutic applications [1][2][3][4][5] . The tubular structure of magnetic nanotubes provides an obvious advantage as their distinctive inner and outer surfaces can be differently functionalized.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of hematite and maghemite nanotubes and study of their applications in neuroscience and drug delivery

et al. 2011

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This report discusses our work on synthesis of hematite and maghemite nanotubes, analysis of their biocompatibility with pheochromocytoma cells (PC12 cells), and study of their applications in the culture of dorsal root ganglion (DRG) neurons and the delivery of ibuprofen sodium salt (ISS) drug model. Two methods, template-assisted thermal decomposition method and hydrothermal method, were used for synthesizing hematite nanotubes, and maghemite nanotubes were obtained from the synthesized hematite nanotubes by thermal treatment. The crystalline, morphology and magnetic properties of the hematite and maghemite nanotubes were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and vibrating sample magnetometer (VSM), respectively. The biocompatibility of the synthesized hematite nanotubes was confirmed by the survival and differentiation of PC12 cells in the presence of the hematite nanotubes coupled to nerve growth factor (NGF). To study the combined effects of the presence of magnetic nanotubes and external magnetic fields on neurite growth, laminin was coupled to hematite and maghemite nanotubes, and DRG neurons were cultured in the presence of the treated nanotubes with the application of external magnetic fields. It was found that neurons can better tolerate external magnetic fields when magnetic nanotubes were present. Close contacts between nanotubes and filopodia that were observed under SEM showed that the nanotubes and the growing neurites interacted readily. The drug loading and release capabilities of hematite nanotubes synthesized by hydrothermal method were tested by using ibuprofen sodium salt (ISS) as a drug model. Our experimental results indicate that hematite and maghemite nanotubes have good biocompatibility with neurons, could be used in regulating neurite growth, and are promising vehicles for drug delivery.

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“…The increased magnetization has led to fast relaxation rates in several one-dimensional designs compared to spherical NPs. [34][35][36][37][38] While one-dimensional nanostructures have exhibited desirable properties for MRI applications, the fabrication methods to control the linear structure and the spatial placement of different materials have been a challenge. Ligand-controlled, template-directed and self-assembly methods are studied for fabrication of one-dimensional nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Proton Relaxation for Enzyme‐Manipulated, Multicomponent Gold–Magnetic Nanoparticle Chains

et al. 2010

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Longitudinal and transverse relaxation times of multicomponent nanoparticle (NP) chains are investigated for their potential use as multifunctional imaging agents in magnetic resonance imaging (MRI). Gold NPs (ca. 5 nm) are arranged linearly along double-stranded DNA, creating gold NP chains. After cutting gold NP chains with restriction enzymes (EcoRI or BamHI), multicomponent NP chains are formed through a ligation reaction with enzyme-cut, superparamagnetic NP chains. We evaluate the changes in relaxation times for different constructs of gold-iron oxide NP chains and gold-cobalt iron oxide NP chains using 300 MHz (1)H NMR. In addition, the mechanism of proton relaxation for multicomponent NP chains is examined. The results indicate that relaxation times are dependent on the one-dimensional structure and the amount of superparamagnetic NP chains present in the multicomponent constructs. Multicomponent NP chains arranged on double-stranded DNA provide a feasible method for fabrication of multifunctional imaging agents that improve relaxation times effectively for MRI applications.

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Synthesis of Superparamagnetic Nanotubes as MRI Contrast Agents and for Cell Labeling

Cited by 53 publications

References 49 publications

Biodegradable magnetic-fluorescent magnetite/poly(dl-lactic acid-co-α,β-malic acid) composite nanoparticles for stem cell labeling

Biodegradable magnetic-fluorescent magnetite/poly(dl-lactic acid-co-α,β-malic acid) composite nanoparticles for stem cell labeling

Synthesis of hematite and maghemite nanotubes and study of their applications in neuroscience and drug delivery

Mechanism of Proton Relaxation for Enzyme‐Manipulated, Multicomponent Gold–Magnetic Nanoparticle Chains

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