Biodegradable magnetic-fluorescent magnetite/poly(dl-lactic acid-co-α,β-malic acid) composite nanoparticles for stem cell labeling

Wang, Liang; Neoh, K. G.; Kang, En‐Tang; Shuter, Borys; Wang, Shih‐Chang

doi:10.1016/j.biomaterials.2010.01.081

Cited by 109 publications

(65 citation statements)

References 57 publications

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“…Wang et al fabricated 100 nm poly(D,L-lactic acid-co-α,β-malic acid) nanoparticles that contained about 8% magnetite. 163 The superparamagnetic nanoparticles labeled human mesenchymal cells in vitro without damaging their ability to proliferate. Lim et al formulated PLGA nanoparticles that contained magnetite cores.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Sah¹,

Thoma²,

Desu³

et al. 2013

IJN

193

127

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Abstract:The functionality of bare polylactide-co-glycolide (PLGA) nanoparticles is limited to drug depot or drug solubilization in their hard cores. They have inherent weaknesses as a drug-delivery system. For instance, when administered intravenously, the nanoparticles undergo rapid clearance from systemic circulation before reaching the site of action. Furthermore, plain PLGA nanoparticles cannot distinguish between different cell types. Recent research shows that surface functionalization of nanoparticles and development of new nanoparticulate dosage forms help overcome these delivery challenges and improve in vivo performance. Immense research efforts have propelled the development of diverse functional PLGA-based nanoparticulate delivery systems. Representative examples include PEGylated micelles/nanoparticles (PEG, polyethylene glycol), polyplexes, polymersomes, core-shelltype lipid-PLGA hybrids, cell-PLGA hybrids, receptor-specific ligand-PLGA conjugates, and theranostics. Each PLGA-based nanoparticulate dosage form has specific features that distinguish it from other nanoparticulate systems. This review focuses on fundamental concepts and practices that are used in the development of various functional nanoparticulate dosage forms. We describe how the attributes of these functional nanoparticulate forms might contribute to achievement of desired therapeutic effects that are not attainable using conventional therapies. Functional PLGA-based nanoparticulate systems are expected to deliver chemotherapeutic, diagnostic, and imaging agents in a highly selective and effective manner.

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Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Sah¹,

Thoma²,

Desu³

et al. 2013

IJN

193

127

View full text Add to dashboard Cite

show abstract

“…The strategy of magnetic separation of magnetic nanoparticles is typically more effective than filtration or centrifugation as it prevents loss of the catalyst. Furthermore, Fe 3 O 4 nanoparticles have showed potential applications in many other fields [7][8].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Microwave-assisted Fe3O4 nanoparticles catalyzed synthesis of chromeno[1,6]naphthyridines in aqueous media

Dandia

Parewa

Gupta

et al. 2015

Catalysis Communications

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“…Multiple imaging modalities have been utilized, including MRI [54][55][56][57][58] , positron emission tomography (PET) [59][60][61][62] , single photon emission computed tomography [63] , bioluminescence imaging [64,65] , fluorescence imaging [66][67][68][69][70][71][72] and computed tomography (CT) [73] . MRI has been accepted as the best modality given its high spatial resolution (< 100 microns), prolonged effective imaging window, lack of ionizing radiation and ability to provide detailed anatomical information [74,75] .…”

Section: Current Imaging Techniquesmentioning

confidence: 99%

Mesenchymal stem cell tracking in the intervertebral disc

Handley

Goldschlager

Oehme

et al. 2015

WJSC

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Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc (IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management, including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging (MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD.

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Biodegradable magnetic-fluorescent magnetite/poly(dl-lactic acid-co-α,β-malic acid) composite nanoparticles for stem cell labeling

Cited by 109 publications

References 57 publications

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Concepts and practices used to develop functional PLGA-based nanoparticulate systems

Microwave-assisted Fe3O4 nanoparticles catalyzed synthesis of chromeno[1,6]naphthyridines in aqueous media

Mesenchymal stem cell tracking in the intervertebral disc

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