Synthesis of <sup>64</sup>Cu-Radiolabeled Folate-Conjugated Iron Oxide Nanoparticles for Cancer Diagnosis

Park, Seungil; Cho, Bo-Bae; Anusha, J.R.; Jung, Soon-Jae; Raj, C. Justin; Kim, Byung Chul

doi:10.1166/jnn.2020.17205

Cited by 14 publications

(7 citation statements)

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“…Like other NPs, they have been conjugated with targeting moieties to improve tumor detection with successful results [ 67 , 69 , 72 ]. Two studies [ 66 , 68 ] examined the integrity and distribution of these NPs after their injection in vivo using radionuclides as tracers.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles and Radioisotopes: A Long Story in a Nutshell

et al. 2022

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The purpose of this narrative review was to assess the use of nanoparticles (NPs) to deliver radionuclides to targets, focusing on systems that have been tested in pre-clinical and, when available, clinical settings. A literature search was conducted in PubMed and Web of Science databases using the following terms: “radionuclides” AND “liposomes” or “PLGA nanoparticles” or “gold nanoparticles” or “iron oxide nanoparticles” or “silica nanoparticles” or “micelles” or “dendrimers”. No filters were applied, apart from a minimum limit of 10 patients enrolled for clinical studies. Data from some significant studies from pre-clinical and clinical settings were retrieved, and we briefly describe the information available. All the selected seven classes of nanoparticles were highly tested in clinical trials, but they all present many drawbacks. Liposomes are the only ones that have been tested for clinical applications, though they have never been commercialized. In conclusion, the application of NPs for imaging has been the object of much interest over the years, albeit mainly in pre-clinical settings. Thus, we think that, based on the current state, radiolabeled NPs must be investigated longer before finding their place in nuclear medicine.

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Section: Resultsmentioning

confidence: 99%

Nanoparticles and Radioisotopes: A Long Story in a Nutshell

et al. 2022

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“…Therefore, the antifungal activity of the liquid culture was concluded as the influence of the content of element Er (x = n) in the synthesized nanomaterial. Various studies have previously reported the bioactivities of metal-substituted NPs such as zinc, nickel, manganese, and copper [ 31 , 32 ] The influence of element Er on the antibacterial properties has been demonstrated in another report [ 33 ] against different types of strains, Escherichia coli , Staphylococcus aureus , Enterococcus faecalis , and Pseudomonas aeruginosa , with decreased levels of toxicity against the tested Desmodesmus subspicatus . However, the antifungal activity of this rare combination of ultrasonicated Mn 0.5 Zn 0.5 Er x Y x Fe 2−2x O 4 nanoparticles is the first of its kind, to the best of our knowledge.…”

Section: Resultsmentioning

confidence: 99%

Ultrasonic Synthesis and Biomedical Application of Mn0.5Zn0.5ErxYxFe2−2xO4 Nanoparticles

et al. 2021

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In the present study, biocompatible manganese nanoparticles have been linked with zinc and iron molecules to prepare different derivatives of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs (x = 0.02, 0.04, 0.06, 0.08, 0.10), using an ultrasonication approach. The structure, surface morphology, and chemical compositions of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs were elucidated by X-ray diffractometer (XRD), High-resolution transmission electron microscopy (HR-TEM), scanning electron microscope (SEM), and Energy Dispersive X-Ray Analysis (EDX) techniques. The bioactivity of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs on normal (HEK-293) and (HCT-116) colon cancer cell line was evaluated. The Mn0.5Zn0.5ErxYxFe2−2xO4 NPs treatment post 48 h resulted in a significant reduction in cells (via MTT assay, having an IC50 value between 0.88 µg/mL and 2.40 µg/mL). The specificity of Mn0.5Zn0.5ErxYxFe2−2xO4 NPs were studied by treating them on normal cells line (HEK-293). The results showed that Mn0.5Zn0.5ErxYxFe2−2xO4 NPs did not incur any effect on HEK-293, which suggests that Mn0.5Zn0.5ErxYxFe2−2xO4 NPs selectively targeted the colon cancerous cells. Using Candida albicans, antifungal activity was also studied by evaluating minimum inhibitory/fungicidal concentration (MIC/MFC) and the effect of nanomaterial on the germ tube formation, which exhibited that NPs significantly inhibited the growth and germ tube formation. The obtained results hold the potential to design nanoparticles that lead to efficient bioactivity.

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“…The new type of SIONs showed excellent performance in lung (A549) cancer cell lines. Radio-thin-layer chromatography (TLC) analysis showed that SIONs with a radiochemical purity of 82.17% and stability of ∼90% in human serum for 24 h. 114 4.…”

Section: Inorganic Nanosystemsmentioning

confidence: 99%

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

et al. 2023

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Synthesis of ⁶⁴Cu-Radiolabeled Folate-Conjugated Iron Oxide Nanoparticles for Cancer Diagnosis

Cited by 14 publications

References 0 publications

Nanoparticles and Radioisotopes: A Long Story in a Nutshell

Nanoparticles and Radioisotopes: A Long Story in a Nutshell

Ultrasonic Synthesis and Biomedical Application of Mn0.5Zn0.5ErxYxFe2−2xO4 Nanoparticles

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

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Synthesis of 64Cu-Radiolabeled Folate-Conjugated Iron Oxide Nanoparticles for Cancer Diagnosis

Cited by 14 publications

References 0 publications

Nanoparticles and Radioisotopes: A Long Story in a Nutshell

Nanoparticles and Radioisotopes: A Long Story in a Nutshell

Ultrasonic Synthesis and Biomedical Application of Mn0.5Zn0.5ErxYxFe2−2xO4 Nanoparticles

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

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Synthesis of ⁶⁴Cu-Radiolabeled Folate-Conjugated Iron Oxide Nanoparticles for Cancer Diagnosis