Synthesis of ¹²³I‐4‐(3‐dimethylaminopropylamino)‐7‐iodoquinoline

Abstract

a potential localizing agent for melanoma, was prepared by isotopic exchange between 1231-iodide and the phosphate or sulphate of IAQ. Yields up to 96% were obtained. The total time for preparation is restricted to 30 minutes.

Radioiodination techniques for small organic molecules

“…262 An iodinated quinoline derivative labeled with 123I has been prepared in modest yield by recoil labeling. 263 The reactions of radioactive recoil atoms with aromatic compounds have been reviewed recently. 264 This method does require access to a cyclotron and associated facilities.…”

Iodine

“…The reaction proceeds largely with inversion of configuration, although the inversion does not appear to be complete. (55) Another useful protocol involves conversion of alcohols to iodides with triphenylphosphine and iodine. In a synthesis of ( + )-discodermolide, 110 Smith and co-workers treated the alcohol shown in eq 56 with triphenylphosphine, imidazole, and iodine in 1:2 benzene:ether and obtained a 95% yield of the primary iodide.…”