Synthesis of Substituted Phenethylamine-Based Thioureas and Their Antimicrobial and Antioxidant Properties

Özgeriş, Bünyamin

doi:10.1134/s1070428021030143

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…The minimum inhibitory concentrations (MICs) were found to be in the range of 0.5 to 64 μg mL −1 for the tested bacterial strains ( A. baumannii , A. iwoffii , Enterobacter sp., E. coli , S. aureus , P. aeruginosa , S. typhi , S. dysenteriae and S. maltophilia ) and of 0.25 to 2 μg mL −1 for Candida species ( Figure 2 ). Özgeriş [ 21 ] synthesized nicotinoyl compounds 30 – 34 by reaction of nicotinoyl chloride with potassium thiocyanate or ammonium thiocyanate to get nicotinoyl isothiocyanate, which refluxed with substituted phenethylamines in acetone to yield the nicotinoyl thioureas ( Scheme 6 ). All compounds showed excellent antibacterial activity against the tested bacterial strains S. aureus , E. faecalis , E. coli , A. baumannii , and P. aeruginosa with MIC concentrations of 31.25 to 62.5 μg mL −1 .…”

Section: Synthesis Of Antimicrobial Compounds Containing Only Pyridin...mentioning

confidence: 99%

Pyridine Compounds with Antimicrobial and Antiviral Activities

Marinescu

Popa

2022

IJMS

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In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2 virus, finding new antiviral and antimicrobial compounds is a priority in current research. Pyridine is a privileged nucleus among heterocycles; its compounds have been noted for their therapeutic properties, such as antimicrobial, antiviral, antitumor, analgesic, anticonvulsant, anti-inflammatory, antioxidant, anti-Alzheimer’s, anti-ulcer or antidiabetic. It is known that a pyridine compound, which also contains a heterocycle, has improved therapeutic properties. The singular presence of the pyridine nucleus, or its one together with one or more heterocycles, as well as a simple hydrocarbon linker, or grafted with organic groups, gives the key molecule a certain geometry, which determines an interaction with a specific protein, and defines the antimicrobial and antiviral selectivity for the target molecule. Moreover, an important role of pyridine in medicinal chemistry is to improve water solubility due to its poor basicity. In this article, we aim to review the methods of synthesis of pyridine compounds, their antimicrobial and antiviral activities, the correlation of pharmaceutical properties with various groups present in molecules as well as the binding mode from Molecular Docking Studies.

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Section: Synthesis Of Antimicrobial Compounds Containing Only Pyridin...mentioning

confidence: 99%

Pyridine Compounds with Antimicrobial and Antiviral Activities

Marinescu

Popa

2022

IJMS

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“…Positive controls for the study's antibacterial and antifungal tests were Netilmicin and amphotericin B, respectively. In each test, DMSO was utilized as a negative control (Ozgeris, 2021).…”

Section: Research On Microbes Utilizing Disc Diffusion Analysismentioning

confidence: 99%

Biological Evaluation of Azide Derivative as Antibacterial and Anticancer Agents

et al. 2022

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Azides are significant compounds because of their biological effects on bacteria, viruses, fungi, and cancer. The antibacterial and anticancer properties of azide derivatives have been demonstrated in several microbial strains and cancer cell lines. The most significant microorganisms in command of hospital-acquired nosocomial infections include Acinetobacter baumannii (A. baumannii), Methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans (C. albicans), and Candida dubliniensis (C. dubliniensis). These infections have become resistant to a variety of antibiotics. These resistant infections are frequently seen in cancer patients. Novel drug-active compounds are thus required that have both antibacterial and anticancer activity. This study examined previously synthesized 1-azido-5,6,7-trimethoxy-2,3-dihydro-1H-indene (4) for its antibacterial and anticancer activities. Antimicrobial activity was assessed using the disc diffusion technique, and minimum inhibitory concentration values were computed for zone formation in the examined pathogens. The study's findings indicate that while azide derivatives did not exhibit any effect against other pathogens, they suppressed bacterial growth with a zone diameter of 10 mm against A. baumannii. The MIC values of azide derivative against A. baumannii were 3.90 µg/ml. WST-8 analysis in Caco-2 cancer and healthy fibroblast cell line was used to determine the anticancer study. As a result of this analysis, the IC50 value was calculated to be 2.99 µM. There is little anticancer activity. A very low toxic effect of the azide compound on fibroblast cells was also observed. These findings suggest that this azide derivative may be tested as a potential antibacterial and anticancer agent.

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“…36 We demonstrated this situation in our previously reports. 13,32 It is known that the central metal atom in metal complexes contributes positively to antioxidant activity as a result of enhancing the proton donating capacity of the ligand. 37 As with benzoyl or N, N'-disubstituted thioureas, both manganese complex 6 and our previously synthesized nicotinoyl thiourea 5 were determined to have antioxidant activities.…”

Section: Characterizationmentioning

confidence: 99%

“…Evidenced by our previously studies that nicotinoyl thioureas comprising aniline ring having methoxy group at different positions have stronger activity than benzoyl thioureas 13,32. It has been determined that compounds containing thiocarbonyl, carbonyl and amine groups have antibacterial properties especially against gram-negative bacteria…”

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confidence: 97%

A novel nicotinoyl thiourea manganese complex: synthesis, characterization, and biological activity studies

Özgeriş

Yıldırım

Görmez

et al. 2021

International Journal of Chemistry and Technology

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In this study, nicotinoyl thiourea synthesized by starting from nicotinic acid and 3,5-dimethoxy aniline according to the literature. The resulting product was reacted with Manganese (II) acetate tetrahydrate and nicotinoyl thiourea manganese complex was synthesized with a metal-ligand ratio of 1: 1. The chemical structure of newly synthesized metal complex was characterized by FTIR, HRMS, XRD, and elemental analysis. In the second part of the study, the antibacterial and antioxidant activities of the synthesized metal complex were investigated. According to the obtained results, metal complex did not show any antibacterial activity. However, metal complex exhibited strong or equipotent antioxidant properties compared to standard antioxidants in DPPH, ABTS, and Cuprac methods. For this reason, metal complex can be evaluated as an antioxidant agent in food protection and the treatment of many diseases related oxidative stress.

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Synthesis of Substituted Phenethylamine-Based Thioureas and Their Antimicrobial and Antioxidant Properties

Cited by 10 publications

References 24 publications

Pyridine Compounds with Antimicrobial and Antiviral Activities

Pyridine Compounds with Antimicrobial and Antiviral Activities

Biological Evaluation of Azide Derivative as Antibacterial and Anticancer Agents

A novel nicotinoyl thiourea manganese complex: synthesis, characterization, and biological activity studies

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