Synthesis of some Pyrimidine-2-one and Pyrimidine-2-thione Compounds

Ebraheem, Hiba A.

doi:10.33899/rjs.2013.67577

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Additionally, they display a variety of biological activities such as antioxidants, antifungals, and antimicrobial actions (A. Ebraheem, 2013). The heterocyclic ring compounds usually contain two or more different elements, oxygen (o), nitrogen (n), and sulfur (s) (Abd El-Sattar et al, 2018;Asad et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

A stepwise synthetic approach and antibacterial assessment of some new pyrazoline derivatives containing azo and benzyloxy moieties

2023

ZJPAS

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This study has designed an efficient stepwise synthesis to produce some new pyrazoline derivatives that contains azo and benzyloxy linkages. The Synthesis route was initiated by diazotizing p-aminocetophenone with 2,6-dichlorophenol to give azo compound (1), which was then reacted with benzyl bromide producing the efficacious core material azo-benzyloxy acetophenone (2). Moreover, compound (2) was treated with a series of substituted benzaldehydes to form intermediate chalcone derivatives (3a-j) which were then treated with phenylhydrazine via Michael type addition reaction to form azo-benzyloxy pyrazoline molecules (4a-j). Ultimately, the structures of the synthesized compounds were revealed using spectroscopic techniques: FT-IR, 1 H-NMR, 13 C-NMR, and 13 C-DEPT-135 spectra. Antimicrobial activities were screened for synthezied Azo-chalcones and Pyrazolines against S.aureus as gram-positive and E.Coli as gram-negative in comparison to a standard antibiotic drug Azithromycine.

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Section: Introductionmentioning

confidence: 99%

A stepwise synthetic approach and antibacterial assessment of some new pyrazoline derivatives containing azo and benzyloxy moieties

2023

ZJPAS

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Synthesis of diverse novel compounds with anticipated antitumor activities starting with biphenyl chalcone

Ismail

El‐Sayed

2020

Journal of Heterocyclic Chem

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The chalcone as (E)‐1‐([1,1′‐biphenyl]‐4‐yl)‐3‐(3,4‐dimethoxyphenyl)prop‐2‐en‐1‐one (3) was reacted with various active methylene compounds via Michael addition reaction under different conditions. In one hand, chalcone 3 reacted with isatin and glycine in one pot reaction via 1,3‐dipolar cycloaddition reaction. On the other hand, chalcone 3 was also reacted with different N‐nucleophiles via direct addition on the carbonyl group to award cyclic and/or acyclic products. Meanwhile, the reaction of chalcone 3 with S‐benzylthiuronium chloride afforded the thio‐Michael addition product. Chalcone 3 and 10 novel synthesized compounds were screened against two cell lines (HepG2 and MCF‐7). Among of them, thiosemicarbazone 16, oxime 14 and pyrimidine‐2(1H)‐thione 19 derivatives revealed an excellent activity against both cell lines (IC50 values = 6.79‐12.91 μM), whereas thiosemicarbazone 16 (6.79 ± 0.5 and 7.58 ± 0.6 μM) showed the highest activity.

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Green synthesis of 4,6-bisarylpyrimidin-2(1H)-ones and azo-linked 4-arylpyrimidin-2(1H)-ones using NiFe2O4@SiO2Pr@glucose amine as a mild nano catalyst

Nikpassand

hoseinnezhad²

2020

Arabian Journal of Chemistry

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Synthesis of some Pyrimidine-2-one and Pyrimidine-2-thione Compounds

Cited by 4 publications

References 6 publications

A stepwise synthetic approach and antibacterial assessment of some new pyrazoline derivatives containing azo and benzyloxy moieties

A stepwise synthetic approach and antibacterial assessment of some new pyrazoline derivatives containing azo and benzyloxy moieties

Synthesis of diverse novel compounds with anticipated antitumor activities starting with biphenyl chalcone

Green synthesis of 4,6-bisarylpyrimidin-2(1H)-ones and azo-linked 4-arylpyrimidin-2(1H)-ones using NiFe2O4@SiO2Pr@glucose amine as a mild nano catalyst

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