Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity

Synthesis of Some 2-(3-Alkyl/aryl-5-trifluoromethylpyrazol-1-yl)-4-(coumarin-3-yl)thiazoles as Novel Antibacterial Agents

“…Many of these compounds have proved to be active as, antibacterial, [21][22][23][24] antitumor, [25] anticoagulant, [26] antiviral, [27] and antiinflammatory [28][29] agents. In addition, these compounds are used as additives to food and cosmetics.…”

N'-Benzylidene-N-(Thiazolyl)Acetohydrazide Derivatives: Synthesis and Antimicrobial Activity Evaluation

“…antiinflamatory [2], antimicrobial [3][4][5][6][7], anticonvulsant [8], anti-tumor [9], antifungal [10,11], or antioxidant representatives [12,13]. Continuing our studies devoted to the chemical synthesis of new thiazole derivatives [14][15][16][17][18][19], in this work we report four new N'-benzylidene-N-(thiazolyl)acetohydrazide derivatives. The antimicrobial activity screening against several Gram positive and Gram negative bacteria strains reported in this study included both the newly synthesized (thiazolyl)acetohydrazide derivatives and the parent 2-(2-benzylidenehydrazinyl)thiazole derivatives which were previously synthesized by Hantzsch condensation of arylidene-thiosemicarbazones with α-halogenocarbonyl derivatives [14] …”

Heterocycles 38. Biocatalytic Synthesis of New Heterocyclic Mannich Bases and Derivatives

“…In addition, aromatic heterocyclic ring systems have a great value in the field of medicinal chemistry, being responsible for a variety of biological activities. In particular, the thiazole ring is a pharmacophore group intensely studied due to OPEN ACCESS its remarkable biological potential, including anti-inflammatory [3], antitumor [4], antibacterial [5], and antiviral [6] properties. The thiophene and furane moieties have attracted special interest in the development of new potent analgesic [7], anti-inflammatory [8], antimicrobial [9], and anticonvulsant [8] agents.…”

“…As a continuation of research devoted to the development of mild and eco-friendly biocatalytic synthetic routes and being aware of the pharmacological value of nitrogen, sulfur and oxygen containing heterocycles [3][4][5][6][7][8][9], we decided to exploit the potential of the lipase-catalyzed direct Mannich reaction by implementing for the first time this enzymatic reaction in the series of heterocyclic compounds. The novel obtained heterocyclic Mannich bases could have promising applications in medicinal chemistry, due to the therapeutic potential of the heterocyclic side chain and his multiple functionalization.…”

“…Br), 149 (4), 93 (18), 77 (15), 43 (100), 39 (12), 27 (2). butan-2-one (5e): yellow liquid, yield: 76%, 1 H-NMR (600 MHz, CDCl3) δ 7.…”