Synthesis of some novel dimethine, bis-dimethine cyanine dyes and octacosamethine cyanine dyes endowed with promising biological potency against (HepG2), (Hela), (MCF-7), (MIA), (SN12C) and (H358) cell lines

El‐Mekawy, Rasha E.; Fadda, Ahmed A.

doi:10.1016/j.bmcl.2018.04.032

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…This is important for many vital applications. One of the most important types of compounds are cyanine dyes, 8–11 which have positive effects on photocatalytic activity (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

“…Cyanine compounds are distinguished by their broad absorbance in the UV-vis region, molar extinction coefficient, and Stokes shift. 39–42 Hence, cyanine dye is highly attractive for use in the field of H 2 energy. The design of photocatalysts is not the only factor affecting the H 2 evolution process, the structure of the photoreactor also has a significant impact on the production rate.…”

Section: Introductionmentioning

confidence: 99%

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Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO₂

Almazroai

El‐Mekawy

Musa³

et al. 2022

RSC Adv.

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“…This is important for many vital applications. One of the most important types of compounds are cyanine dyes, 8–11 which have positive effects on photocatalytic activity (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO₂

Almazroai

El‐Mekawy

Musa³

et al. 2022

RSC Adv.

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“…The cyanine dyes consisting of two nitrogen‐containing heterocyclic structures connected by a polymethine bridge are a subject of permanent scientific interest due to their wide range of applications in the areas of science, technology, engineering, and medicine . They are employed in industrial paints for trapping solar energy, as lasers and photorefractive materials, as antitumor agents, and as probes in biological systems . Because the possibilities of utilization of cyanine dyes strongly depend on their structure and even minor changes in heterocyclic moieties, in the number of methine groups located in the connecting bridges, or the presence of certain substituents have a huge impact on the compounds' properties, there is a need for the development of fast and simple methods for their structural characterization.…”

Section: Introductionmentioning

confidence: 99%

“…1 They are employed in industrial paints for trapping solar energy, as lasers and photorefractive materials, [2][3][4] as antitumor agents, and as probes in biological systems. [5][6][7] Because the possibilities of utilization of cyanine dyes strongly depend on their structure and even minor changes in heterocyclic moieties, in the number of methine groups located in the connecting bridges, or the presence of certain substituents have a huge impact on the compounds' properties, [8][9][10] there is a need for the development of fast and simple methods for their structural characterization.…”

Section: Introductionmentioning

confidence: 99%

Electrospray ionization collision induced dissociation of thiocarbocyanine and selenocarbocyanine dyes

Kaczorowska

Jędrzejewska

2019

J Mass Spectrom

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The effect of the properties of sulphur and selenium atoms, the composition and location of substituents (―CH3, ―OCH3, ―C2H5, and ―C3H6―((N+Br−)C5H5)), and the charge state on the collision induced dissociation (CID) behaviour of ions generated by electrospray ionization (ESI) of thiocarbocyanine and selenocarbocyanine dyes have been investigated. The results show that, for of all the examined singly charged ions, the main dissociation channel was related to the formation of distonic ions, generated as a result of cleavages within the dimethine bridge. In the case of doubly charged ions (with propyl‐pyridinium substituents), competition between fragmentation processes related to charges located at different nitrogen atoms has been observed. The S/Se replacement also has an impact on the CID behaviour of the examined carbocyanine dyes. On the basis of the performed CID MS/MS experiments, general rules for the CID of thiocarbocyanine and selenocarbocyanine dyes have been proposed.

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Synthesis of novel cyanine dyes as antitumor agents

Fadda

Tawfik

Abdel‐Motaal

et al. 2020

Archiv der Pharmazie

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In this study, some novel cyanine dyes, 1, 3, and 5−15, were synthesized by a one‐pot step reaction of pyridinium salts 2 and/or 4 with benzenaminium salt 1. N‐{[1‐Chloro‐3,4‐dihydronaphthalen‐2‐yl)methylene]benzenaminium} chloride 1 was obtained by the reaction of α‐tetralone with Vilsmeier−Haack reagent, followed by a mixture of an equimolar ratio of anilin/ethanol (1:1). All new cyanine dyes were evaluated in vitro for their anticancer activity against two cell lines, that is, HepG2 (human hepatocellular liver carcinoma) and MCF‐7 (breast cancer). The obtained results were compared with human lung fibroblasts (WI‐38) and Vero cells (derived from the kidney of an African green monkey) as normal cells. In particular, some of these compounds, 6, 9, 13, and 14, were found to be the most potent derivatives against all the cancer cell lines, without effect on the normal cells. According to the structure–activity relationship, compound 13 (IC50 = 8.8 µg/ml) exhibited a higher activity against HepG2 cells, as it contains the azo group and two phenyl rings and due to the presence of the π‐conjugated system attached to the two pyridine rings. Compound 6 (IC50 = 8 µg/ml) exhibited a higher activity against MCF‐7 cells, as it contains two chlorine atoms and the π‐conjugated system of the pyridine rings.

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Synthesis of some novel dimethine, bis-dimethine cyanine dyes and octacosamethine cyanine dyes endowed with promising biological potency against (HepG2), (Hela), (MCF-7), (MIA), (SN12C) and (H358) cell lines

Cited by 10 publications

References 26 publications

Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO₂

Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO₂

Electrospray ionization collision induced dissociation of thiocarbocyanine and selenocarbocyanine dyes

Synthesis of novel cyanine dyes as antitumor agents

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Synthesis of some novel dimethine, bis-dimethine cyanine dyes and octacosamethine cyanine dyes endowed with promising biological potency against (HepG2), (Hela), (MCF-7), (MIA), (SN12C) and (H358) cell lines

Cited by 10 publications

References 26 publications

Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO2

Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO2

Electrospray ionization collision induced dissociation of thiocarbocyanine and selenocarbocyanine dyes

Synthesis of novel cyanine dyes as antitumor agents

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Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO₂

Photocatalytic hydrogen evolution over cyanine-sensitized Ag/TiO₂