Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents

2‐Bromo‐2‐chloro‐3‐arylpropanenitriles can be prepared by Meerwein reaction from 2‐chloroacrylonitrile and various aryldiazonium salts under copper(II) bromide catalysis. They proved to be stable compounds which form 2‐chlorocinnnamonitriles upon treatment with bases. Reaction of the title compounds with substituted thioglycolates gave substituted 3‐aminothiophenes which have not yet been accessible by other routes. Three‐component reactions with the title compound, sodium sulfide and bromonitromethane, chloroacetonitrile, or ethyl 4‐chloroacetoacetate gave 2‐nitro‐ and 2‐cyano‐substituted 3‐aminothiophenes, and thienopyridinediones in high yields and in one single step, respectively.

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2‐Bromo‐2‐chloro‐3‐arylpropanenitriles as C‐3 Synthons for the Synthesis of Functionalized 3‐Aminothiophenes

Batsyts

Shehedyn

Goreshnik

et al. 2019

Eur J Org Chem

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Design and synthesis of novel urea derivatives of pyrimidine-pyrazoles as anticancer agents

Cherukumalli

Tadiboina

Gulipalli

et al. 2022

Journal of Molecular Structure

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Supported Transition Metal Catalysts for Organic Fine Chemical Synthesis: A Review

Mistri¹,

Kumar²

2021

Asian J. Chem.

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Transition metal catalysts play an important role for synthesis of industrially and laboratory important organic fine chemicals to control the selectivity, activity and stability. In this review, we focus on mainly transition metal based supported catalyst, mainly oxide supported catalyst for heterogeneous catalytic hydrogenation and oxidation of some synthetically important organic molecules. First we discuss the industrially important catalytic organic synthetic reactions. This is followed by the role of supported metal catalysts in the heterogeneous synthetic catalytic reactions with specific attention to hydrogenation and oxidation of organic molecules. The role of base metals and noble metals in monometallic and bimetallic catalysts are then discussed. Some synthetic routes for preparation of oxide supported metal catalysts are also discussed. Finally, a general discussion of the metal-support interaction (MSI) in oxide supported metal catalysts is made.

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Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents

Cited by 4 publications

References 21 publications

2‐Bromo‐2‐chloro‐3‐arylpropanenitriles as C‐3 Synthons for the Synthesis of Functionalized 3‐Aminothiophenes

2‐Bromo‐2‐chloro‐3‐arylpropanenitriles as C‐3 Synthons for the Synthesis of Functionalized 3‐Aminothiophenes

Design and synthesis of novel urea derivatives of pyrimidine-pyrazoles as anticancer agents

Supported Transition Metal Catalysts for Organic Fine Chemical Synthesis: A Review

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