Design and synthesis of novel urea derivatives of pyrimidine-pyrazoles as anticancer agents

Cherukumalli, Purna Koteswara Rao; Tadiboina, Bhaskara Rao; Gulipalli, Kali Charan; Bodige, Srinu; Badavath, Vishnu Nayak; Sridhar, Gattu; Gangarapu, Kiran

doi:10.1016/j.molstruc.2021.131937

Cited by 11 publications

(3 citation statements)

References 39 publications

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“…Compound 10 was able to stably bind to the colchicine-binding site on tubulin and induce cell cycle arrest at G2/M phase, leading to apoptosis. Cherukumalli et al prepared a library of novel substituted aryl urea derivatives of pyrimidine-pyrazole as potential antiproliferative agents against four human cancer cell lines (MCF7, A549, Colo205, and A2780) [40]. Among the synthesized derivatives, compound 11 revealed the strongest antiproliferative activity against all tested cell lines with IC50 values ranging from 0.01 to 0.65 µM, superior to the standard drug etoposide.…”

Section: Tubulin Polymerization Inhibitorsmentioning

confidence: 99%

Recent Advances in the Development of Pyrazole Derivatives as Anticancer Agents

Zhang

et al. 2023

IJMS

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Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical structures that confer them with a broad spectrum of pharmacological activities. They have been extensively explored for designing potent and selective anticancer agents. In recent years, numerous pyrazole derivatives have been synthesized and evaluated for their anticancer potential against various cancer cell lines. Structure–activity relationship studies have shown that appropriate substitution on different positions of the pyrazole ring can significantly enhance anticancer efficacy and tumor selectivity. It is noteworthy that many pyrazole derivatives have demonstrated multiple mechanisms of anticancer action by interacting with various targets including tubulin, EGFR, CDK, BTK, and DNA. Therefore, this review summarizes the current understanding on the structural features of pyrazole derivatives and their structure-activity relationships with different targets, aiming to facilitate the development of potential pyrazole-based anticancer drugs. We focus on the latest research advances in anticancer activities of pyrazole compounds reported from 2018 to present.

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Section: Tubulin Polymerization Inhibitorsmentioning

confidence: 99%

Recent Advances in the Development of Pyrazole Derivatives as Anticancer Agents

Zhang

et al. 2023

IJMS

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“…[1] These molecules have been reported to have significant anticancer, antifungal, antibacterial, anti-Alzheimer, anti-inflammatory, antimicrobial and antiviral activities. [2][3][4][5][6][7][8][9][10][11] They have been recognized as an interesting unit of biological activity, and some have also shown significant anticancer activity in many of the human cell lines. [12] Compounds containing propargyl groups play a key role as building blocks in many synthetic transformations and new materials.…”

Section: Introductionmentioning

confidence: 99%

“…Pyridine groups are an important class of heterocycles widely used as pharmaceutical and agrochemicals with many biological activities [1] . These molecules have been reported to have significant anticancer, antifungal, antibacterial, anti‐Alzheimer, anti‐inflammatory, antimicrobial and antiviral activities [2–11] . They have been recognized as an interesting unit of biological activity, and some have also shown significant anticancer activity in many of the human cell lines [12] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, DNA Binding Properties, Molecular Docking and ADME Studies of Schiff Base Compound Containing Pyridine‐Propargyl Group

Güngör

2023

Chemistry & Biodiversity

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The structure of the pyridine‐based Schiff base compound containing the propargyl group was characterized by NMR spectroscopy. Binding of compound 2 with double‐stranded fish sperm DNA (Fsds‐DNA) was investigated using viscosity measurement studies and UV‐Vis and fluorescence spectral techniques. Binding of compound 2 with Fsds‐DNA results in minor hypochromism with no change in absorption maxima and fluorescence quenching with almost no shift in emission maxima, which can be attributed to the groove‐binding mode of the interaction. The binding constant was found to be 4.7 x 104 M‐1. The Fsds‐DNA viscosity measurement, KI quenching and NaCl quenching studies and the competitive interaction between compound 2 and ethidium bromide with DNA confirm the proposed binding mode. In addition, interactions between compound 2 and the DNA double helix were analysed by molecular docking study in order to determine the binding mode and binding affinity. As a result of molecular docking, the binding affinity of the 2‐DNA complex, which has the most stable conformation ‐8.10 kcal/mol and it is located in its minor groove. In addition, molecular docking and ADME studies for compound 2 were also performed.

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