Synthesis of Some New N‐[5‐Methyl‐1‐(4‐chlorophenyl)‐1,2,3‐triazol‐4‐yl]carbamic Acid Ester Derivatives (V)

Quan, Bin; Zhuang, Shan-Xue; Li, Chun‐Cheng; He, Dong

doi:10.1002/chin.200550125

Cited by 1 publication

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“…1), in order to investigate the possibility for their dimethoxytriazine linked to the triazole heterocycle to bind to the zinc atom of this protein. However, we did not succeed in the activation of acids 7a-d [47,48], 2 whatever the conditions tested (SOCl 2 /DMF [49], oxalyl chloride/CH 2 Cl 2 /DMF [50], TFAA/TFA [51]) (Scheme 1; Table 1). Thus, we considered obtaining the target compounds 2a-i starting from acetylenic derivative 1 (Scheme 2).…”

Section: Chemistrymentioning

confidence: 98%

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Synthesis and biological evaluation of a new class of triazin–triazoles as potential inhibitors of human farnesyltransferase

et al. 2015

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A new synthesis of ethynyldimethoxytriazine 1, an important platformcompound for developing new chemical entities for anticancer research and for other biological applications, is described. Compound 1 was further reacted with azides 5a-i to provide triazin-triazoles 2a-i, which were tested on human farnesyltransferase and on the NCI-60 human tumor cell lines. Synthesis of other dimethoxytriazine derivatives 15 and 16, linked to a sp 2 or a sp 3 carbon atom were also studied. Electronic supplementary material The online version of this article (2a-i target compounds CO 2 H 2c: IC 50 (human FTase) = 38.6 µM

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Section: Chemistrymentioning

confidence: 98%

“…Entry 2: Conditions described in reference [50]. Entry 3: Conditions described in reference [49]. Entry 4: Conditions described in reference [51] a Tested conditions resulted in formation of insoluble material Synthesis and biological evaluation of a new class of……”

Section: Chemistrymentioning

confidence: 99%