Synthesis of some new functionalized pyrano[2,3-c]pyrazoles and pyrazolo[4′,3′:5,6] pyrano[2,3-d]pyrimidines bearing a chromone ring as antioxidant agents

Recent advancements in the multicomponent synthesis of heterocycles integrated with a pyrano[2,3-d]pyrimidine core

“…Ali et al 115 have cited a multi-step synthesis of tricyclic systems with comparatively good yields. In this route, enaminonitrile 34 reacted with triethyl orthoformate in acetic anhydride to yield the desired ethyl formimidate 35.…”

“…The basic character of the nanocatalyst enables the carbonyl group activation in condensation with hydrazine for the cyclization of pyrazolone ring, enolization of pyrazolone intermediate, proton abstraction of the active methylene group of (thio)barbituric acids in condensation with aryl aldehydes, and cyclocondensation of pyran ring aer the Michael addition step-mechanism. Ali et al 115 have cited a multi-step synthesis of tricyclic systems with comparatively good yields. In this route, enaminonitrile 34 reacted with triethyl orthoformate in acetic anhydride to yield the desired ethyl formimidate 35.…”

Insights into the recent progress in the medicinal chemistry of pyranopyrimidine analogs

“…Also, the effect of substituents linked to the phenyl ring at the C5 position is preferred to be hydroxy groups or electron-withdrawing groups such as the nitro group linked at the phenyl ring. 81 Ali et al 111 reported the schematic synthesis of the tricyclic systems linked to heterocyclic systems, e.g., pyrazolopyranopyrimidinyl-chromenone analogs 188-193, starting from the reactive precursor, dihydro-pyranopyrazole 186 with enaminonitrile moiety. Compound 188 was synthesized from compound 186 by reaction with formic acid or from compound 187 by reaction with DMF-DMA in dioxane under heating conditions.…”

“…Ali et al 111 reported the schematic synthesis of the tricyclic systems linked to heterocyclic systems, e.g. , pyrazolo-pyranopyrimidinyl-chromenone analogs 188–193 , starting from the reactive precursor, dihydro-pyranopyrazole 186 with enaminonitrile moiety.…”

Design, Synthesis, Molecular Docking, and Evaluation Antioxidant and Antimicrobial Activities for Novel 3-Phenylimidazolidin-4-One and 2-Aminothiazol-4-One Derivatives

“…In this regard, chemists make many and various attempts to discover novel pyrimidine derivatives via different synthetic strategies and utilize various important catalysts [ 13 , 14 , 15 ]. Fused pyrimidines were designed and evaluated as antitumors [ 16 ], antioxidants [ 17 ], and anticancer [ 18 ]. In addition, imidazopyrimidines exhibited highly biological activities where they act as anti-inflammatory [ 19 ], antimicrobial [ 20 ], and cytotoxic agents [ 21 ].…”