Synthesis of Some New bis-Schiff Bases of Isatin and 5-Fluoroisatin in a Water Suspension Medium

Abstract

Abstract:Condensation of aromatic primary bis-amines with isatin (1H-indole-2,3-dione) and 5-flouroisatin occurred cleanly and efficiently in a water suspension medium without using any organic solvent or acid catalyst. The corresponding bis-Schiff bases were obtained in good yields and were easily isolated by filtration. Their structures were confirmed by 1 H-NMR, 13 C-NMR, IR and mass spectra.

Synthesis and Antibacterial Activity of Isatin Schiff Base Derivative with 3-Aminoacetophenone and its Ni(II), Co(II) Transition Metals Complexes

“…Formula: C 8 H 5 NO 2 . Is found in many plants and Schiff bases of Isatin are investigated for their pharmaceutical properties (Jarrahpour and Khalili, 2005). This was prepared according to the literature method, Isatins can be made from the corresponding indole in good yield by a mixing of InCl 3 and IBX in an acetonitrile-water solution at 80°C (Yadav, et al, 2007).…”

“…This was prepared according to the literature method, Isatins can be made from the corresponding indole in good yield by a mixing of InCl 3 and IBX in an acetonitrile-water solution at 80°C (Yadav, et al, 2007). The electrophilic carbon atoms of Isatin carbonyl group can be targets of nucleophilic attack by amines (Jarrahpour and Khalili, 2005). 3-Aminoacetophenone is one of the most typical aromatic carbonyls which show photochemical properties3-aminoacetophenone with molecular formula C 8 H 9 NO, having melting point 96-98°C.…”

Greener Synthetic and Nanotechnological Bridge: Theoretical and Practical Biological Approach Toward the Bactericidal Dual Action Mechanism of Azomethine–Nanosilver Hybrid

“…[2][3][4] They are also used as liquid crystals [5] and in analytical, [6] medicinal, [7] and polymer chemistry. [8] Traditionally, azomethine has been produced by refluxing mixtures of the amine and the carbonyl compound in an organic solvent [9] or azeotroping the mixture with benzene in a DeanStark apparatus in the presence of acid.…”

A New Derivatives of Benzodiazepine, Imidazole, Isatin, Maleimide, Pyrimidine and 1,2,4-Triazole: Synthesis and Characterization

“…Schiff bases belong to a widely used group of organic intermediates important for production of specialty chemicals, e.g., pharmaceuticals, or rubber additives and as amino protective group in organic synthesis. They also use as liquid crystals, and in analytical, medicinal and polymer chemistry 4 .…”