Synthesis of Some Derivatives of Pyrimido[5,4-e]Tetrazolo[5,1-c][1,2,4]triazine; a Novel Heterocyclic System

Abstract

Several new derivatives of pyrimido [5,4-e]tetrazolo [5,1-c][1,2,4]triazine have been synthesised through the reaction of 5-hydrazinyl-1Htetrazole with 5-bromo-2,4-dichloro-6-methylpyrimidine in CHCl 3 solution at ambient conditions. Further treatment of the synthesised compound with secondary amines gave the corresponding substituted heterocycles which were subsequently cyclised into pyrimido [5,4-e] tetrazolo [5,1-c][1,2,4]triazines as derivatives of a novel heterocyclic system on treatment with NaNH 2 in CH 3 CN.

Synthesis, Characterisation, and in Vitro Antibacterial Evaluation of a New Class of 2-substituted-4-methyl-7,8-dihydro-5H-pyrimido[4,5-d]thiazolo[3,2-a] Pyrimidines

“…the related pyrimido [4,5-d]pyrimidine derivatives after the elimination of dimethylamine from the cycloadducts as well as the oxidative aromatisation. 17 In view of these observations and in continuation of our study on fused pyrimidines, [18][19][20][21] we have undertaken the synthesis of some new derivatives of pyrimido [4,5-d]thiazolo [3,2-a] pyrimidine and tested their antibacterial activity.…”

Synthesis and Density Functional Theory Study of [1,2,3]Triazolo[4,5-d][1,2,4] Triazolo[4,3-a]Pyrimidine Derivatives: A Novel Heterocyclic System

“…[17][18][19] Some recently published protocols for assembling this bicyclic system have been accomplished through a one-pot multicomponent reaction using substituted aromatic aldehydes, malononitrile and 3-amino-1,2,4-triazole catalysed by boric acid in aqueous micellar conditions, 20 oxidative cyclisation of 4-amino-6-arylidene(heteroarylmethylidene) hydrazinyl-1,3,5-triazin-2-ones with Pb(OAc) 4 via a Dimroth-type rearrangement, 21 treatment of chloro-5,6diaminopyrimidines with NaNO 2 /HCl 22 and cyclisation of diethyl 2,4,6-trifluorophenylmalonate with 3-amino-1,2,4triazole. 11 Regarding these points, and due to our interest in the synthesis of various fused heterocyclic derivatives with a pyrimidine core, [23][24][25][26][27][28] herein we wish to report a convenient method for…”