Synthesis of Some Biginelli Compounds in Solvent Medium Using a Photochemistry Method

Synthesis of Biginelli Compounds Using Cobalt Hydrogen Sulfate

“…1 The THPMs and their derivatives have shown a wide scope of important pharmacological and biological properties including antibacterial, antifungal, antiviral, antitubercular, anticancer and anti-malarial properties. [2][3][4][5] Due to the biological importance of THPMs, several new and improved procedures by applying microwave, 6 ultrasound 6 or UV irradiations 7 in the presence of various catalysts have been reported. Although many of these methods gave pure tetrahydropyrimidinones in good to excellent yields, but in most cases urea and ethyl acetoacetate were only used as reactants for the synthesis of 5-carboethoxy-2-oxo-1,2,3,4-tetrahydropyrimidines.…”

N-Propylcarbamothioyl benzamide complex of Bi(III) supported on superparamagnetic Fe3O4/SiO2 nanoparticles as a highly efficient and magnetically recoverable heterogeneous nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) via the Biginelli reaction

“…Thus, with the aim of developing a highly efficient synthetic process and in continuation of our previous works [15,[60][61][62], we report preparation of a new Npropylcarbamothioyl benzamide complex of Bi(III) supported on silica-coated Fe 3 O 4 nanoparticles (Fe 3 O 4 /SiO 2 -NH-ligand-Bi(III) MNPs) and its application as an inexpensive, highly efficient and magnetically recoverable heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via the one-pot threecomponent reaction of b-dicarbonyl compounds, aldehydes, and urea/thiourea under solvent-free conditions.…”

Three Component Reaction: An Efficient Synthesis and Reactions of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Using New Natural Catalyst

“…Thus, the Biginelli reaction has received renewed interest from researchers interested in discovering milder and more efficient procedures that are applicable to a wide range of substituents in all three components and proceed in better yields. So, the one-pot-Biginelli protocol for 3,4-dihydropyrimidines synthesis was explored by varying all components and catalysts [10–18] in protic, aprotic solvents, and solvent free conditions [19] using either classical heating, microwave [20, 21], ultrasound [22, 23], and visible light (100 W Lamp, THF) irradiations [24]. Also several improved procedures have been reported recently using not only acidic media such as Lewis acids, protic acids, and ionic liquids as promoters [25, 26] but also nonacidic substances such as baker's yeast [27], graphite [28], and iodine [29, 30].…”