Synthesis of Biginelli Compounds Using Cobalt Hydrogen Sulfate

Memarian, Hamid Reza; Ranjbar, Maryam

doi:10.1002/jccs.201190016

Cited by 10 publications

(8 citation statements)

References 12 publications

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“…The increase of the required irradiation time in the presence of oxygen and also a failure of total quenching under oxygen are supporting the argument that both excited singlet and triplet states of THPMs are involved in the reaction as we also observed by irradiation in CHCl 3 solution [29,30]. The removal of 3-and 4-hydrogens in this study, namely photo-oxidation of THPMs in acetonitrile solution, is probably a result of homolytic cleavage of both C-H and N-H bonds.…”

Section: Photo-oxidationsupporting

confidence: 84%

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Light-induced Free Radical Oxidation of 2-Oxo-1,2,3,4-tetrahydropyrimidines

Memarian

Hejazi

Farhadi

2012

Zeitschrift Für Naturforschung B

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A variety of 4-substituted 5-acetyl-and 5-carboethoxy-2-oxo-1,2,3,4-tetrahydropyrimidines were oxidized under UV irradiation in the presence or absence of benzoyl peroxide. The nature of the substituents on the 4-and 5-positions of the heterocyclic ring affects the rate of photo-oxidation, and irradiation of these compounds in the presence of benzoyl peroxide decreases the time of reaction drastically. Removal of 4-H by a benzoyloxy radical under formation of a trihydropyrimidinoyl radical intermediate occurs in the rate-determining step. The stability of this benzylic and allylic radical intermediate is affected by the nature and the position of the additional substituent on the phenyl group located at C-4.

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Section: Photo-oxidationsupporting

confidence: 84%

“…The title compounds were prepared through a three components condensation using Co(HSO 4 ) 2 [30]. Melting points were determined on a Stuart Scientific SMP2 apparatus and are uncorrected.…”

Section: Methodsmentioning

confidence: 99%

Light-induced Free Radical Oxidation of 2-Oxo-1,2,3,4-tetrahydropyrimidines

Memarian

Hejazi

Farhadi

2012

Zeitschrift Für Naturforschung B

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“…Cobalt hydrogen sulfate Co(HSO 4 ) 2 was prepared according to the method of Memarian et al [18] Polyphosphate ester was synthesized using the procedure reported by Kappe and his colleagues. [19] …”

Section: Synthesis Of the Lewis Acid Catalystsmentioning

confidence: 99%

Design, Synthesis and Molecular Docking Studies of Some Tetrahydropyrimidine Derivatives as Possible Fascin Inhibitors

Riahi

Kefayat

Ghasemi

et al. 2019

Chemistry & Biodiversity

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Eight derivatives of tetrahydropyrimidine scaffold were designed and prepared as hybrid compounds possessing the structural features of both monastrol as an anticancer drug and nifedipine as a fascin blocking agent. All of the compounds were evaluated for their cytotoxic potency and the ability to inhibit 4T1 breast cancer cells migration. Then, they were investigated in silico for their ability to inhibit the fascin protein using molecular docking simulation. The most potent compound was 4d and the weakest one was 4a according to the in vitro cytotoxicity assay. The corresponding IC 50 values were 193.70 and 248.75 μM, respectively. The least cytotoxic compound (4a) was one of the strongest ones in binding to the fascin binding site according to the molecular docking results. 4a and 4e inhibited the 4T1 cells migration better than other compounds. They were more potent than nifedipine in inhibiting the migration process. In silico studies proved 4h to be the most potent fascin inhibitor in terms of ΔG bind although it was not inhibiting migration. The controversy between the in vitro and in silico results may cancel the theory of the involvement of the fascin inhibition in the migration inhibition. However, the considerable antimigratory effects of some of the synthesized compounds encourage performing further in vivo experiments to introduce novel tumor metastasis inhibitors.

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“…[1][2][3] Therefore, because of their importance various works are devoted to the synthesis of these nitrogen containing heterocyclic compounds. [4][5][6] In our previous studies, we were interested in elucidating the parameters affecting the rate of thermal and photochemical oxidation of some nitrogen containing heterocyclic compounds, e.g. 1,4-dihydropyridines (DHPs), [7] 2-oxo-1,2,3,4-tetrahydropyrimidines (THPMs) [8] and 2,3-dihydroquinazolinones (DHQZs).…”

Section: Introductionmentioning

confidence: 99%

“…Tetrahydropyrimidinone (THPMs) derivatives previously known as 3,4‐dihydropyimidine‐2‐( 1H )‐ones (DHPMs) exhibit a wide range of biological activities and pharmaceutical properties . Therefore, because of their importance various works are devoted to the synthesis of these nitrogen containing heterocyclic compounds . In our previous studies, we were interested in elucidating the parameters affecting the rate of thermal and photochemical oxidation of some nitrogen containing heterocyclic compounds, e.g.…”

Section: Introductionmentioning

confidence: 99%