Synthesis of sodium alginate based sprayable new soft gel system

Chhatbar, Mahesh U.; Prasad, Kamalesh; Chejara, Dharmesh R.; Siddhanta, A. K.

doi:10.1039/c2sm06947d

Cited by 30 publications

(31 citation statements)

References 33 publications

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“…This resulted in the formation of hysteresis loop. 23,48 Decrease in the viscosity as the shear rate was increased and formation of hysteresis loop due to closed shear cycle indicate viscoelastic properties of the gels (shear thinning and thixotropy, respectively). 23,49 Though 100% structural recovery was not there, many of the junction points were recovered.…”

Section: Rheological Studiesmentioning

confidence: 99%

Lanolin‐based organogels as a matrix for topical drug delivery

Sagiri

Behera

Pal

et al. 2012

J of Applied Polymer Sci

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The current study deals with the development of lanolin‐based emulsion gels by hot emulsification method. Bright‐field, phase contrast, and fluorescent micrographs of the gels have shown the uniform distribution of circular water droplets in the formulations. Coalescence of water droplets was observed in gels containing higher proportion of water. Fourier transform infrared spectrophotometric studies indicated absence of Ln‐drug chemical interactions. X‐ray diffraction studies suggested an increase in amorphousness of the gels with the incorporation of water into the gel structure. The salicylic acid (SA), model drug, release from the gels was found to follow Higuchi kinetics. Krossmeyer–Peppas model fitting indicated non‐Fickian release of the drug. As the water content of the gels increased, there was a corresponding increase in the rate of release of the drug. The gels showed non‐Newtonian and thixotropic flow behavior. The gel to sol transition and melting temperatures of the gels were identified by differential scanning calorimetric (DSC) thermal analysis and falling ball method. DSC thermograms indicated an increase in thermal stability with the increase of water content in the gels. The gels showed sufficient spreadability and biocompatibility characteristics to be used as topical formulations. SA loaded gels showed good antimicrobial efficacy against Bacillus subtilis, a Gram‐positive bacterium. Based on the preliminary studies, the developed gels may be regarded as carriers in topical drug delivery. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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Section: Rheological Studiesmentioning

confidence: 99%

Lanolin‐based organogels as a matrix for topical drug delivery

Sagiri

Behera

Pal

et al. 2012

J of Applied Polymer Sci

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“…Because of the thixotropic behavior of the samples, their viscosity values are lower in the second shear interval. Besides, the downward curve was always lower than the upward curve, which means that the system's internal structure recovered faster than it was damaged, reflecting its stability (Chhatbar et al, 2012;Dolz et al, 2000).…”

Section: Resultsmentioning

confidence: 99%

Correlation between rheological properties and capillary fixation for modelling creams

Demoliner

Agnol

Zanotti

et al. 2018

Braz. J. Pharm. Sci.

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The Brazilian male beauty market occupies the second place in world consumption of cosmetics. Among the numerous products consumed by such audience is the capillary fixation mask, which is mainly composed by fixatives. These additives act on stabilizing the cosmetic emulsion, protecting the hair against moisture and also increasing the intensity of hair fixation. In this work, three formulations for modelling creams were prepared by different concentrations of the fixatives Styleze TM W20 and PVP K90 and their properties characterized by physicochemical, rheological and sensory analysis. The capillary masks produced were stable oil-in-water (O/W) emulsions with uniform droplets of 2.05-2.82 μm sizes and pseudoplastic thixotropic behavior (0.19 < n < 0.26). It was possible to correlate the increased concentration of PVP K90 to a greater thixotropy and an improved yarn fixation, despite the worsening in the spreadability of the formulations. These results suggest properly conducted rheological measurements can contribute to the prediction of the emulsion's sensory properties, which can save time and funds on the development of new cosmetics.

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“…The viscosity profiles in both the stages did not overlap and did not reach the starting point resulting in the formation of the hysteresis loop (Fig. 3a) [38]. A hysteresis loop was formed due to closed shear cycle suggesting that the gels could not recover their original structure under the experimental conditions.…”

Section: Mechanical Propertiesmentioning

confidence: 96%