Synthesis of Selenium Nanoparticles Stabilized by Quaternary Ammonium Compounds

Blinov, Andrey Vladimirovich; Маглакелидзе, Давид Гурамиевич; Yasnaya, M.A.; Gvozdenko, Alexey Alekseevich; Blinova, A. A.; Golik, Alexey Borisovich; Slyadneva, Kristina Sergeevna; Pirogov, Maxim Alexandrovich

doi:10.1134/s1070363222030094

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…Analysis of the resulting histogram showed that the average hydrodynamic radius of Se NPs was 28 ± 8 nm, which corresponds to the TEM results and is similar to the data described in the previous work 76 .…”

Section: Resultssupporting

confidence: 88%

Effect of selenium nanoparticles on biological and morphofunctional parameters of barley seeds (Hordéum vulgáre L.)

Nagdalian

Blinov

Siddiqui

et al. 2023

Sci Rep

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The purpose of this work was to study the effect of selenium nanoparticles (Se NPs) on the biological and morphofunctional parameters of barley seeds (Hordéum vulgáre L.) We used seeds of Hordéum vulgáre L. with reduced morphofunctional characteristics. For the experiment, Se NPs were synthesized and stabilized with didecyldimethylammonium chloride. It was found that Se NPs have a spherical shape and a diameter of about 50 nm. According to dynamic light scattering data, the average hydrodynamic radius of the particles was 28 ± 8 nm. It is observed that the nanoparticles have a positive ζ-potential (+ 27.3 mV). For the experiment, we treated Hordéum vulgáre L. seeds with Se NPs (1, 5, 10 and 20 mg/L). The experiment showed that treatment of Hordéum vulgáre L. seeds with Se NPs has the best effect on the length of roots and sprout at concentration of 5 mg/L and on the number and thickness of roots at 10 mg/L. Germinability and germination energy of Hordéum vulgáre L. seeds were higher in group treated with 5 mg/L Se NPs. Analysis of macrophotographs of samples, histological sections of roots and 3D visualization of seeds by microcomputing tomography confirmed the best effect at 5 mg/L Se NPs. Moreover, no local destructions were detected at concentrations > 5 mg/L, which is most likely due to the inhibition of regulatory and catalytic processes in the germinating seeds. the treatment of Hordéum vulgáre L. seeds with > 5 mg/L Se NPs caused significant stress, coupled with intensive formation of reactive oxygen species, leading to a reorientation of root system growth towards thickening. Based on the results obtained, it was concluded that Se NPs at concentrations > 5 mg/L had a toxic effect. The treatment of barley seeds with 5% Se NPs showed maximum efficiency in the experiment, which allows us to further consider Se NPs as a stimulator for the growth and development of crop seeds under stress and reduced morphofunctional characteristics.

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Section: Resultssupporting

confidence: 88%

Effect of selenium nanoparticles on biological and morphofunctional parameters of barley seeds (Hordéum vulgáre L.)

Nagdalian

Blinov

Siddiqui

et al. 2023

Sci Rep

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“…However, the problem is that generics are not so easy to produce [21]. Of all the substitution requirements, it is easiest to achieve substance equivalence, that is, to synthesize the same substance as in the original.…”

Section: The State Of the Russian Pharmaceutical Market From The Poin...mentioning

confidence: 99%

Socio-Demographic and Economic Factors of the Pharmaceutical Market Development in Russia

Ismailov¹,

Lazareva²,

Родионова³

et al. 2022

Pharmacophore

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“…Nutraceutical supplements made of collagen amino acids help weakened children strengthen cartilage, bone, and other connective tissues (Khatri et al, 2021). The use of nutraceuticals from collagen hydrolysates in combination with glycosaminoglycans, vitamins, and metal cations can stimulate the biosynthesis of macromolecules in cells and the structure of the extracellular matrix, disrupted as a result of diseases (Cardoso et al, 2014;Mobasheri et al, 2021;Blinov et al, 2022). If the action of modern medicines is aimed at reducing inflammatory and painful symptoms during the disease or its exacerbation, then nutraceuticals have an advantage in preventing diseases (Alanazi et al, 2019;Mostafavi et al, 2019;Son et al, 2021).…”

Section: Nutritionology In the Prevention Of Joint Diseasesmentioning

confidence: 99%

Collagen Hydrolysates in the Prevention and Treatment of Arthritis

Kryuchkova¹,

Tunguzbieva²,

Tokaeva³

et al. 2022

J Biochem Technol

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The present review examines the role of collagen hydrolysates in the treatment and prevention of joint diseases. Collagen is the main structural protein of bones, cartilage, ligaments, and tendons in joints. Hydrolyzed collagen, as a source of specific amino acids, can be a building material for the formation of collagen fibrils in connective tissues. Enzymatic hydrolysis of chicken cartilage made it possible to obtain a complex of collagen type II hydrolysate and glycosaminoglycans. In clinical studies, hydrolysates of cutaneous collagen, type II cartilaginous collagen, and type II non-denatured cartilaginous collagen were tested. The use of collagen hydrolysates for a long time (5-6 months) allowed for improving the functioning of the knee joint in patients not only with mild but also with severe osteoarthritis. Nutraceuticals from type II collagen hydrolysates in combination with vitamin C more effectively affect the formation of collagen fibrils, and proteoglycans in the cartilage matrix and thus can affect the increase in joint mobility. Nutriciology, as a branch of modern biopharmaceutics, represents its new direction and explores possible mechanisms and ways to prevent human diseases.

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Synthesis of Selenium Nanoparticles Stabilized by Quaternary Ammonium Compounds

Cited by 9 publications

References 24 publications

Effect of selenium nanoparticles on biological and morphofunctional parameters of barley seeds (Hordéum vulgáre L.)

Effect of selenium nanoparticles on biological and morphofunctional parameters of barley seeds (Hordéum vulgáre L.)

Socio-Demographic and Economic Factors of the Pharmaceutical Market Development in Russia

Collagen Hydrolysates in the Prevention and Treatment of Arthritis

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