Synthesis of pyridazine derivatives—V

Nucleophilic substitution reactions, molecular aggregation, structure and lipophilicity of 6-chloro-3-chloromethyl-1,2,4-triazolo[4,3-b]pyridazine

“…3-Chloro-6-hydrazinopyridazine was obtained from 3,6-dichloropyridazine using hydrazine hydrate. 17 Chloromethyl phenyl sulfone, and chloromethyl p-tolyl sulfone were prepared by known methods. 18,19 α-Chloroethyl-, α-chloropropyl phenyl sulfone, and α-chloroethyl p-tolyl sulfone were synthesized by alkylation of chloromethyl phenyl-or p-tolyl sulfone in a catalytic two-phase system.…”

Organoiodine(III)‐mediated efficient synthesis of new 3,9‐diaryl‐bis‐1,2,4‐triazolo[4,3‐a][4,3‐c]pyrimidines

“…In an analogous manner, we attempted the preparation of 4a by the reaction of 6 with benzoic acid/benzoyl chloride under various conditions [10]. Although we were successful in obtaining dibenzoylamino derivative 7, the cyclization of the latter did not give any acceptable result to obtain the desired product 4a (Scheme 3).…”

Synthesis of new derivatives of 3‐aryl‐1,5‐dimethyl‐1H‐[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5‐e][1,3,4]oxadiazines as potential antiproliferative agents

“…Numerous methods for the synthesis of 1,2,4-triazoles have been reported in the literature, which includes utilizing toxic reagents such as phosphorus oxychloride [12], lead tetraacetate [12,13], and bromine [13,14] as well as other oxidative reagents like chloramines T [15], iodobenzene diacetate [16,17], iron(III) chloride [18], and CuCl 2 [19]. The synthesis of 1,2,4-triazoles through electrochemical method [20] have also been reported.…”