Synthesis of pyrazolo[3,4-b]pyridines under microwave irradiation in multi-component reactions and their antitumor and antimicrobial activities – Part 1

Synthesis of novel pyridine linked to benzimidazole via sulphide and their Antioxident and Antimicrobial activity

“…1 H NMR spectra were recorded on a Bruker 400 MHz spectrometer. 13 C NMR spectra were recorded on Bruker 100 MHz spectrometer by using DMSO-d6 as a solvent and TMS as an internal standard. The chemical shifts are expressed in δ ppm.…”

“…The authors are thankful to the University of Mysore for providing the lab facility and Institution of Excellence for providing the instrumentation facility for 1 HNMR, 13 C NMR and LC-MS analysis.…”

“…The mass spectrum of the compound (6b) showed (M+H) ion at m/z 337.1133. The 1 H, 13 C NMR and Mass spectral data of all compounds is included in the experimental section.…”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…Thus, in the presence of a catalytic amount of Yb(OTf)3 and under MW irradiation with silica gel, several series of 2-amino-3- On the other hand, El-Borai et al [31] described a new synthesis of pyrazolo [3,4-b]pyridine derivatives through a one-pot multi-component reaction. In this synthesis, 5-amino-1-phenyl-3-(pyridin-3-yl)-1H-pyrazole (11) was allowed to react with either 4-anisaldehyde (12) and p-substituted α-keto-nitriles 13 or with pyruvic acid (16) and some aromatic aldehydes 15 in acetic acid (Scheme 2).…”

“…A wide range of practical syntheses of pyridine derivatives using MW-irradiation have been reported in the last decade [30][31][32][33][34]. In a recent work, Hu et al [30] synthesized a series of novel polyfunctionalized pyrido [2,3-b]indoles.…”