Synthesis of Pyrano[2, 3-d]Pyrimidine-2,4(3H)-Dione Derivatives Based-on Curcumin Using NiCo₂O₄@OCMC@Zn(BDC) Nanocomposite as a Novel and Efficient Catalyst

The Michael donor–acceptor reactivity of curcumins in the synthesis of diverse multi-functional scaffolds

“…This journal is © The Royal Society of Chemistry 2024 Ghasemzadeh's group synthesized almost similar pyrano [2, 3-d]pyrimidine-2,4(3H)-diones from curcumin 23 with aromatic aldehyde 11 and 1,3-dimethyl barbituric acid by using NiCo 2 O 4 @OCMC@Zn(BDC) nanocomposite as Lewis acid. 62 Subsequently, Adibi and Khodarahmi synthesized curcuminbased anti-oxidant pyrano [2,3-d]pyrimidine-2,4(3H)-diones 83 by a similar one-pot reaction catalyzed by borax. 63 The synthesized derivatives were screened and found to have potential inhibitory activities against α-glucosidase(α-Glu) and α-amylase (α-Amy).…”

Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)

“…Then Najafi et al 81 prepared a Lewis acidic NiCo 2 O 4 @OCMC@Zn(BDC) as an efficient nanocomposite (10 mg) in the treatment of discrete 1 (1 mmol) with 11a (1 mmol) and the yellow pigment curcumin 22 (1 mmol) as a naturally occurring 1,3-dicarbonyl compound which afforded 48 in aqueous ethanol under reflux ( Scheme 33 ). As the reaction terminated, dichloromethane was added to the crude reaction mixture in which the catalyst remains insoluble and separated with the help of a magnet and was furthermore used without a loss of its effectiveness for the next six runs.…”

Curcumin‐based bioactive heterocycles derived via multicomponent reactions

“…Najafi et al [ 95 ] reported the synthesis of curcumin‐based pyrano[2,3‐ d ] pyrimidine‐2,4(3 H )‐dione derivatives 26 via a three‐component reaction of curcumin 1 , aromatic aldehydes 4 , and 1,3‐dimethylbarbituric acid 25 in the presence of NiCo 2 O 4 @OCMC@Zn(BDC) nanocomposite as a catalyst in high yields (79%–95%) with short time (4–6 h) (Scheme 8). The nanocomposite acts as a Lewis acid and enhances the electrophilicity of the carbonyl group of the aldehydes 4 and curcumin 1 by forming a coordinate bond.…”