Curcumin‐based bioactive heterocycles derived via multicomponent reactions

Abstract

Curcumin is an important phytochemical, found in the Asian countries, especially in the Indian subcontinent. The use of this "privileged natural product" in the diversityoriented synthesis of curcumin-based heterocycles via multicomponent reactions (MCRs) is the subject of interest for many medicinal chemists across the globe. This review particularly focuses on the reactions involving curcuminoids as one of the reactants in the MCRs of curcuminoid to synthesize curcumin-based heterocycles.Also, the various pharmacological activities of curcumin-based heterocycles generated via the MCR approach are discussed. The research work published in the last 10 years is in the focus of this review article.

The Michael donor–acceptor reactivity of curcumins in the synthesis of diverse multi-functional scaffolds

“…Curcumin can participate in multicomponent reactions and deliver the corresponding hybrid products in a step-economic fashion. 50 Although metal-catalyzed Michael reactions of curcumin are not extensively explored, some well-established reactions have been documented in the past few years. As part of investigating the reactivity of various 1,3-dicarbonyls, Reddy et al investigated a one-pot multicomponent reaction of curcumin 23 , aryl aldehyde 11 and kojic acid 59 to construct dihydropyrano[3,2- b ]chromenedione skeletons 60 in 65% yield in the presence of metal-based Lewis acid InCl 3 (Scheme 18).…”

Synthesis of the first 4-oxobutane-1,1,2,2-tetracarbonitriles containing a phenol fragment and their transformation into cyano-substituted pyrrol-2-ones showing three-position molecular switching

“…Diversity-oriented synthesis (DOS) is one of the effective approaches for preparation of small molecules with various practically useful properties. [1][2][3][4][5][6][7][8][9][10] Thus, based on DOS processes, various biologically active compounds, [1][2][3][4][5][6] luminescent sensors and probes, 8 AIE-luminogens 9 and inaccessible macrocycles 10 have been synthesized. The substrates used in the DOS strategy are quite diverse.…”