Synthesis of Potential Dual Antagonists III

Mechanisms of Reactions of Ring-Substituted Bis(1-aziridinyl) phosphinyl Urethan Antineoplastic Agents

“…The synthesis and physicochemical properties of the ring-substituted bis-aziridinylphosphinyl carbamates 111 and V were previously reported (10). The trans-2,3-dimethyl analog, IV, was synthesized according to the same general procedure, by the reaction of dichlorophosphinyl urethan with ~~-trans-2,3-dimethylaziridine (IX).…”

“…The syntheses of Compounds 1-111 and V were previously reported (1,2,10). Hydrolysis Products-The final hydrolysis products of III-V were obtained by incubating 0.015 mole of each compound with 2.2 moles of deionized distilled water at 37" for 3 weeks.…”

Synthesis of Potential Dual Antagonists IV.

“…A phenyl trimethyl ammonium chloride, 1piperidine carboxylate) in appropriate concentrations inhibits stem elongation of plants (1)(2)(3)(4)(5)(6). It is classified as a growth retardant, i.e., a chemical that slows cell division and cell elongation in shoot tissues and regulates plant height physiologically without formative effects (1).…”

Synthesis of bis(aziridinyl)phosphinyl-N-hydroxyurethane derivatives as antineoplastic agents

“…To test this hypothesis, we synthesized a new series of "dual antagonists" (3)(4)(5)(6) in which the bifunctional alkylating moieties were linked to A^-hydroxyurethane rather than urethane. Presumably, these compounds would release on hydrolysis directly N-hydroxyurethane rather than urethane and, therefore, may prove to be more effective antitumor agents when compared to the previously studied series in the absence of X-irradiation.…”