Mechanisms of Reactions of Ring-Substituted Bis(1-aziridinyl) phosphinyl Urethan Antineoplastic Agents

Synthesis of bis(aziridinyl)phosphinyl-N-hydroxyurethane derivatives as antineoplastic agents

“…From a structural point of view, the hydroxyurethane moiety can be linked to a bis(l-aziridinyl)phosphinyl group either through a P-0 or through a P-N bond. The hydroxyl group of N-hydroxyurethane (7) is more reactive than the amide group toward acylation27 as well as alkylation.28 Reaction of 7 with 1 mol equiv of t Presented in part at the 166th National Meeting of the American Chemical Society, Chicago, 111., August 27-30,1973, Abstracts, MEDI 1.…”

Reactions of 2,2-dimethylaziridine-type Alkylating Agents in Biological Systems I: Colorimetric Estimation and Stability in Physiological Media

“…In view of the unique chemical and pharmacological properties (2,7,8,22,26) of these 2,2-dimethylaziridine derivatives as compared to their ring-C-unsubstituted aziridine analogs [i.e., the conventional "ethyleniminetype" alkylating agents, bis( 1 -aziridinyl)phosphinylurethan (IV), triethylenemelamine (V), tris( 1-aziridiny1)-phosphine oxide (VI), etc.] and in view of their apparently selective chemotherapeutic effects (26), it appeared worthwhile to investigate the reactions of these compounds in biological systems.…”