Synthesis of Polyvinyl Pirrolidone (PVC) /Κ-Carrageenan Hydrogel Prepared by Gamma Radiation Processing As a Function of Dose and PVP Concentration

Erizal, Erizal; Tjahyono, Tjahyono; PP, Dian; Darmawan, Darmawan

doi:10.22146/ijc.21324

Cited by 13 publications

(9 citation statements)

References 19 publications

(24 reference statements)

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“…The spectrum of the unirradiated sample (S-0) indicates the absorbance peak at 845 cm –1 corresponding to the characteristic (PVP) rings. 52 The peak at 1019 cm –1 represents the functional group C–N in (PVP) rings. 53 …”

Section: Resultsmentioning

confidence: 99%

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Improvement of In Vitro Dissolution of the Poor Water-Soluble Amlodipine Drug by Solid Dispersion with Irradiated Polyvinylpyrrolidone

et al. 2020

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The aim of this study was to increase both the rates of dissolution and bioavailability of the amlodipine (Amlo) drug. Due to the low cost, high solubility, and amorphous state, polyvinylpyrrolidone (PVP) has been used as a drug carrier in the solid dispersion process. Through applying an irradiation technique, powder of (PVP) is irradiated with six 0–50 kGy irradiation doses. The six irradiated (PVP) samples were characterized using gel permeation chromatography, electron spin resonance, and Fourier transform infrared (FT-IR) spectroscopy. The formulation of six (PVP/Amlo) samples at a ratio of 2:1 wt/wt were characterized using FT-IR spectroscopy and X-ray powder diffraction. In vitro dissolution of (Amlo) drug was assessed in a water solvent at pH 1.2 and pH 7. Results demonstrated that there is a change in the physicochemical properties of irradiated (PVP). FT-IR confirmed that there is an intermolecular H bond between the (Amlo) drug and (PVP) polymer. XRD confirmed that (PVP) changes the crystalline (Amlo) to amorphous amlodipine. Irradiated (PVP) at a dose of 20 kGy released approximately 89% from 40 mg of (Amlo) in 60 s. The in vitro rate of amlodipine dissolution depends on the drug–polymer intermolecular H bond. The rate of (Amlo) dissolution is increased due to the drug–drug intramolecular hydrogen bonding replaced with the drug–polymer intermolecular hydrogen bonding, which reduces the crystal packing. Irradiated (PVP) improved the rate of (Amlo) dissolution compared to unirradiated (PVP).

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Section: Resultsmentioning

confidence: 99%

“…FT-IR spectra of the non-irradiated and irradiated (PVP) powders at different doses are shown in Figure . The spectrum of the unirradiated sample (S-0) indicates the absorbance peak at 845 cm –1 corresponding to the characteristic (PVP) rings . The peak at 1019 cm –1 represents the functional group C–N in (PVP) rings …”

Section: Resultsmentioning

confidence: 99%

Improvement of In Vitro Dissolution of the Poor Water-Soluble Amlodipine Drug by Solid Dispersion with Irradiated Polyvinylpyrrolidone

et al. 2020

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“…These results indicate that the synthetic polymer PVP is miscible with the natural polymer CRG. It has been shown that the frequency of C=O stretch is very sensitive to hydrogen bond formation with water molecules [49]. The pyrrolidone rings in PVP contain a proton accepting carbonyl moiety, whereas CRG presents hydroxyl as a hydrogen donor [49].…”

Section: Preparation and Characterization Of Niacinamide-loaded Hybri...mentioning

confidence: 99%

“…It has been shown that the frequency of C=O stretch is very sensitive to hydrogen bond formation with water molecules [49]. The pyrrolidone rings in PVP contain a proton accepting carbonyl moiety, whereas CRG presents hydroxyl as a hydrogen donor [49]. Therefore, hydrogen bonding interactions may take place between these two chemical moieties in blends of CRG and PVP.…”

Section: Preparation and Characterization Of Niacinamide-loaded Hybri...mentioning

confidence: 99%

Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect

et al. 2021

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Niacinamide (NIA) has been widely used in halting the features of ageing by acting as an antioxidant and preventing dehydration. NIA’s physicochemical properties suggest difficulties in surpassing the barrier imposed by the stratum corneum layer to reach the target in the skin. To improve cutaneous delivery of NIA, a hybrid nanogel was designed using carrageenan and polyvinylpyrrolidone polymers combined with jojoba oil as a permeation enhancer. Three different types of transethosomes were prepared by the thin-film hydration method, made distinct by the presence of either an edge activator or a permeation enhancer, to allow for a controlled delivery of NIA. Formulations were characterized by measurements of size, polydispersity index, zeta potential, encapsulation efficiency, and loading capacity, and by evaluating their chemical interactions and morphology. Skin permeation assays were performed using Franz diffusion cells. The hybrid hydrogels exhibited robust, porous, and highly aligned macrostructures, and when present, jojoba oil changed their morphology. Skin permeation studies with transethosomes-loaded hydrogels showed that nanogels per se exhibit a more controlled and enhanced permeation, in particular when jojoba oil was present in the transethosomes. These promising nanogels protected the human keratinocytes from UV radiation, and thus can be added to sunscreens or after-sun lotions to improve skin protection.

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“…The advantages of radiation technique application are easy process control, simultaneously hydrogel formation and sterilization in one step process, no need any initiators and crosslinkers ect. This makes irradiation, as one of the best choice for the preparation method of hydrogels [12]. However, some researchers have been reported on the radiation of acrylic acid aimed to prepare hydrogels [13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization Superabsorbent Hydrogels of Partially Neutralized Acrylic Acid Prepared Using Gamma Irradiation; Swelling and Thermal Behavior

Erizal

Abbas

Sukaryo³

et al. 2015

Indones. J. Chem.

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Synthesis of Polyvinyl Pirrolidone (PVC) /Κ-Carrageenan Hydrogel Prepared by Gamma Radiation Processing As a Function of Dose and PVP Concentration

Abstract: ABSTRACT

Cited by 13 publications

References 19 publications

Improvement of In Vitro Dissolution of the Poor Water-Soluble Amlodipine Drug by Solid Dispersion with Irradiated Polyvinylpyrrolidone

Improvement of In Vitro Dissolution of the Poor Water-Soluble Amlodipine Drug by Solid Dispersion with Irradiated Polyvinylpyrrolidone

Topical Delivery of Niacinamide to Skin Using Hybrid Nanogels Enhances Photoprotection Effect

Synthesis and Characterization Superabsorbent Hydrogels of Partially Neutralized Acrylic Acid Prepared Using Gamma Irradiation; Swelling and Thermal Behavior

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