Synthesis of polyfunctional triethoxysilanes by ‘click silylation’

Singh, Gurjaspreet; Mangat, Satinderpal Singh; Singh, Jandeep; Arora, Aanchal; Sharma, Ramesh K.

doi:10.1016/j.tetlet.2013.12.037

Cited by 38 publications

(23 citation statements)

References 47 publications

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“…All carboxylic acids, 3‐chloropropyltriethoxysilane (3‐ClPTES), sodium azide, bromotris(triphenylphosphine)copper(I) (CuBr(PPh 3 ) 3 ), tetraethyl orthosilicate (TEOS) and propargyl alcohol were used directly as received. 3‐Azidopropyltriethoxysilane (3‐AzPTES) was prepared from substitution reaction of 3‐ClPTES with sodium azide . 1 H NMR and 13 C NMR spectra were recorded with a JEOL (AL 400 MHz) spectrometer using CDCl 3 as an internal reference and chemical shifts were measured relative to tetramethylsilane.…”

Section: Methodsmentioning

confidence: 99%

An expedient ‘click’ approach for the synthetic evaluation of ester‐triazole‐tethered organosilica conjugates

Singh

Rani

2017

Applied Organom Chemis

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The present work articulates the synthesis of a new series of organo‐functionalized triethoxysilanes derived from versatile carboxylic acids and 3‐azidopropyltriethoxysilane in excellent yields. A proficient and convenient route implicating the Cu(I)‐catalysed 1,3‐cycloaddition of organic azide with terminal alkynes, labelled as click silylation, has been developed for the generation of ester‐triazole‐linked alkoxysilanyl scaffolds (4a–f). All the synthesized compounds have been thoroughly characterized using elemental analysis and Fourier transform infrared, 1H NMR and 13C NMR spectroscopic techniques. Importantly, the fabricated alkoxysilanes are potentially amenable for an in situ sol–gel condensation reaction with silica nanospheres leading to the incorporation of organic functionality via covalent grafting onto the nanostructured particle system. As a proof of concept, a one‐pot preparation of organic–inorganic hybrid nanoparticles is presented using bis‐silane 4 f. The efficiency and selectivity of the prepared nanocomposite towards metal ions is highlighted using adsorption experiments, and the immobilized nanoparticles present a high sensing efficiency towards Cu2+ and Pb2+ ions while demonstrating better response than that of the bulk material.

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Section: Methodsmentioning

confidence: 99%

An expedient ‘click’ approach for the synthetic evaluation of ester‐triazole‐tethered organosilica conjugates

Singh

Rani

2017

Applied Organom Chemis

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“…"Click" chemistry is preferred to insert a triazole linker between two subsequent units having a great significance in formation of new biomaterials with unique physical and chemical properties. [8][9][10][11][12][13][14][15] In 1,4-disubstituted 1,2,3-triazole, high dipole moment make it hydrogen bond acceptor and attribute to binding ability towards biological sites and improving properties. Benzothiazole and triazole based derivatives also showed inhibitory activity due to interaction of electron rich heteroatoms with active site of various enzymes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Immobilization of Benzothiazole‐Appended Triazole‐Silane: Biological Evaluation and Molecular Docking Approach

et al. 2018

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The present work involves the synthesis of Benzothiazole capped triazole‐silane (3) by ‘Click Silylation’ and its immobilization onto silica surface. This new silane is characterised by IR, 1H, 13C spectroscopy. TGA, TEM and SEM were the evidence for its adsorption at silica surface. The anti‐parasitic, anti bacterial and anti oxidant activity of synthesised compounds was evaluated. The results shows that nanoparticle of silane displayed more significant activity as compared to benzothiazole derived silane (3) against G. lamblia, T. vaginalis, various bacterial strains (E.coli, Bacillus subtillus, Staphylococcus aureus, Vibrio cholera) and showed potential anti‐oxidant activity. Further Molecular docking study was performed to analyse the binding manner and enzyme inhibitory activity of compound‐3 with β‐glucuronidase.

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“…Due to this arrangement, silatranes have attracted the attention of scientists worldwide who are keen to study silatranes by varying exocyclic substituent that affects the steric and electronic characteristics of the silatranes [3,4]. Recently, we have worked on the modification at axial position of silatranes with various derivatives [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, electronic absorption and antimicrobial studies of N-(silatranylpropyl)phthalimide derived from phthalic anhydride

Singh

Saroa

Girdhar

et al. 2015

Inorganica Chimica Acta

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Synthesis of polyfunctional triethoxysilanes by ‘click silylation’

Cited by 38 publications

References 47 publications

An expedient ‘click’ approach for the synthetic evaluation of ester‐triazole‐tethered organosilica conjugates

An expedient ‘click’ approach for the synthetic evaluation of ester‐triazole‐tethered organosilica conjugates

Synthesis and Immobilization of Benzothiazole‐Appended Triazole‐Silane: Biological Evaluation and Molecular Docking Approach

Synthesis, characterization, electronic absorption and antimicrobial studies of N-(silatranylpropyl)phthalimide derived from phthalic anhydride

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