Synthesis and Immobilization of Benzothiazole‐Appended Triazole‐Silane: Biological Evaluation and Molecular Docking Approach

Abstract

The present work involves the synthesis of Benzothiazole capped triazole‐silane (3) by ‘Click Silylation’ and its immobilization onto silica surface. This new silane is characterised by IR, 1H, 13C spectroscopy. TGA, TEM and SEM were the evidence for its adsorption at silica surface. The anti‐parasitic, anti bacterial and anti oxidant activity of synthesised compounds was evaluated. The results shows that nanoparticle of silane displayed more significant activity as compared to benzothiazole derived silane (3) against G. lamblia, T. vaginalis, various bacterial strains (E.coli, Bacillus subtillus, Staphylococcus aureus, Vibrio cholera) and showed potential anti‐oxidant activity. Further Molecular docking study was performed to analyse the binding manner and enzyme inhibitory activity of compound‐3 with β‐glucuronidase.

Applications of medicinal chemistry for drug discovery against Acanthamoeba infections

“…The compounds of this class have been investigated and found effective against different parasites. 101 Ozpinar et al, 102 studied benzothiazole against Acanthamoeba castellanii for the first time. They investigated the effect of these compounds against the trophozoites and cyst of Acanthamoeba castellanii.…”

“…The compounds of this class exhibit a variety of biological properties. The compounds of this class have been investigated and found effective against different parasites 101 …”

Riluzole, a Derivative of Benzothiazole as a Potential Anti-Amoebic Agent against Entamoeba histolytica

“…Among the beneficial biological and pharmacological properties of benzothiazole derivatives are their anticancer [ 14 ], antimicrobial [ 15 ], antidiabetic [ 16 ], anticonvulsant [ 17 ], anti-inflammatory [ 18 ], antiviral [ 19 ], and antitubercular activities [ 20 ]. In relation to their antiparasitic activities, they have been described as [ 21 , 22 , 23 ] leishmanicidal [ 24 , 25 ], anthelmintic [ 26 ], antimalarial [ 27 ], and trypanocidal [ 28 , 29 , 30 ].…”

Benzothiazole Encapped Silane and Its Nano Composites for Sequential Detection of Copper Ions and Cysteine in Aqueous Solution

“…In the present work, benzothiazole encapped silane (synthesized in our previous work) and its nanoparticles have been studied for chemosensing with essential trace metals [16] . Trace elements present in the humans play a critical role in a variety of biochemical processes of organisms [17–24] .…”

“…[14][15] In the present work, benzothiazole encapped silane (synthesized in our previous work) and its nanoparticles have been studied for chemosensing with essential trace metals. [16] Trace elements present in the humans play a critical role in a variety of biochemical processes of organisms. [17][18][19][20][21][22][23][24] Further, association complex of compound-K3 with copper/amino acid (cysteine) were evaluated with the help of different photophysical properties, which assist us to appraise efficiency towards biological systems.…”