Synthesis of Polycaprolactone Nanoparticles through Flow‐Focusing Microfluidic‐Assisted Nanoprecipitation

Heshmatnezhad, Fazlollah; Nazar, Ali Reza Solaimany

doi:10.1002/ceat.202000222

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Thus, selecting the right type of surfactants with an optimal concentration is important. [119] Moreover, the HFF device can be used for making hybrid polymer NPs by using different synthetic polymers with different ratios, e.g., hybrid polymer NPs comprised of PCL and poly(trimethylene carbonate) homopolymers, and PLGA/PLGA-PEG NPs. [120,121] To increase the throughput of polymer NP production, one way is to increase the polymer concentration or its flow rate.…”

Section: Synthetic Polymer Npsmentioning

confidence: 99%

Microfluidic Nanoparticles for Drug Delivery

Liu

Yang

Hui

et al. 2022

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Nanoparticles (NPs) have attracted tremendous interest in drug delivery in the past decades. Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability in precisely controlling NP properties. The recent success of mRNA vaccines using microfluidics represents a big milestone for microfluidic NPs for pharmaceutical applications, and its rapid scaling up demonstrates the feasibility of using microfluidics for industrial‐scale manufacturing. This article provides a critical review of recent progress in microfluidic NPs for drug delivery. First, the synthesis of organic NPs using microfluidics focusing on typical microfluidic methods and their applications in making popular and clinically relevant NPs, such as liposomes, lipid NPs, and polymer NPs, as well as their synthesis mechanisms are summarized. Then, the microfluidic synthesis of several representative inorganic NPs (e.g., silica, metal, metal oxide, and quantum dots), and hybrid NPs is discussed. Lastly, the applications of microfluidic NPs for various drug delivery applications are presented.

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Section: Synthetic Polymer Npsmentioning

confidence: 99%

Microfluidic Nanoparticles for Drug Delivery

Liu

Yang

Hui

et al. 2022

Small

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“…Compared with conventional methods suggested for NP synthesis, in MF‐based procedures, the size of NPs can be regulated perfectly through adjustable FFRs. [ 69 ] Thus, finely tuned size and uniform size distribution attest to the superiority of MF‐based procedures in the fabrication of NPs. For example, in the synthesis of PLGA NPs, the size of the particles drastically depends on the PLGA concentration and the allowed time for precipitation.…”

Section: Advantages Of Microfluidic‐based Nps In Drug Deliverymentioning

confidence: 99%

A Comprehensive Review of One Decade of Microfluidic Platforms Applications in Synthesis of Enhanced Carriers Utilized in Controlled Drug Delivery

Siavashy,

Soltani,

Ahmadi

et al. 2022

Adv Materials Technologies

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Physical and chemical characteristics of NPs highly depend on their shapes, sizes, structures, morphologies, surface properties, and chemical compositions, [8,9] which are modifiable. In addition, NPs can carry small molecules, imaging agents, deoxyribonucleic acid (DNA), antibodies, peptides, proteins, or other substances to specific parts of the body. [10,11] On the other hand, investigations on different diseases have confirmed the need for a paradigm shift in the development of drugs and delivery systems. Hence, developing novel therapeutics and delivery approaches to treat diseases is a significant problem. [12] Therefore, many novel strategies based on innovative solutions have been developed. [13][14][15] Among these strategies, the synthesis of nanocarriers using microfluidic (MF) technology has become popular in recent years. This multidisciplinary technology is a unique platform for chemistry, medicine, pharmacy, physics, biology, materials science, fluid mechanics, and engineering. [16,17] Specifically, it has played a pivotal role in developing drug delivery systems. [18][19][20] Therefore, it is crucial to study MF experiments' practical potential and advantages over conventional methods. Furthermore, considering a high surface-to-volume ratio in MFs, they require fewer chemical reagents and generate less waste, making them suitable for Novel nanocarriers such as multifunctional nanoparticles (NPs) have recently attracted attention due to their various applications, specifically in medicine and treatment. However, it is vital that these particles be synthesized with meticulous control of different structural, chemical, and physical properties. In response to this demand, microfluidic (MF) technology as a reliable procedure can provide promising results in the development of desired NPs and efficient drug delivery systems. By controlling the flow rates of multiphase fluids and conditions of chemical reactions, MF technology enables the fabrication of uniform and highly stable particles with enhanced surfaces, higher encapsulation efficiency, and controlled release of therapeutic agents compared with conventional bulk methods. This review article investigates the MF-based methods utilized in the synthesis of NPs and their advantages in developing novel drug delivery systems. It also provides a comprehensive comparison with conventional methods from a different point of view, emphasizing a novel category of nanocarriers' critical characteristics. In addition, a summary of the most recent representative works on NPs fabrication by MF procedures is presented, and their potential and applications in drug delivery are discussed.The ORCID identification number(s) for the author(s) of this article can be found under

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