Synthesis of polybutylene succinate via Lipase-Catalyzed Transesterification: Enzyme Stability, reuse and PBS properties in bulk polycondensations

Enzymatic Synthesis of Hydroxy-Functionalized Glycerol-Based Polyesters: A Study of Functionalization, Regioselectivity Control, and Catalyst Reuse

“…22 Enzymatic direct esterification may present low reaction rates due to solubility restrictions of succinic acid in the reaction medium within the usual enzyme activity temperature range, 40−90 °C. 23 Transesterification reactions using diethyl or dimethyl succinate do not present solubility restrictions in the polyol in this temperature range. It is worth mentioning that transesterification reactions at relatively low reaction times and mild temperatures require the use of catalysts.…”

“…As a consequence, the polymerization degree and average molar masses decrease, as the reaction rates become controlled by mass transfer effects due to the lower temperatures. 30 The influence of diols on the physical properties of polyesters has also been investigated. For example, the insertion of 1,3-propanediol (PDO) into different building blocks promotes a decrease in crystallinity and melting point, as well as an increase in the elasticity and enzymatic degradation rate of aliphatic copolyesters such as poly-(propylene succinate-co-butylene succinate) (PPBS).…”

“…Immobilized lipases have been used in succinic polyester production, including direct esterification, transesterification, and ring-opening polymerizations . Enzymatic direct esterification may present low reaction rates due to solubility restrictions of succinic acid in the reaction medium within the usual enzyme activity temperature range, 40−90 °C . Transesterification reactions using diethyl or dimethyl succinate do not present solubility restrictions in the polyol in this temperature range.…”

“…Conversely, the use of lower temperatures (below 90 °C) increases the reaction medium viscosities as well as the mass transfer resistance of monomers and polymeric species in the bulk reaction medium and through biocatalyst pores. As a consequence, the polymerization degree and average molar masses decrease, as the reaction rates become controlled by mass transfer effects due to the lower temperatures …”

Current Status and Perspectives on the Green Synthesis of Succinic Polyesters for Value‐Added Applications

“…[ 22 ] This type of catalyst enables milder reaction temperatures, high selectivity, and products free of metal deposition. [ 20 ] Moreover, there is also the possibility of reuse of the biocatalyst, when immobilized, [ 23 ] being an alternative to the conventional oligomerization process with metallic catalysts. Particularly, enzymatic polycondensation processes of renewable monomers are an alternative with lower environmental impact, both in terms of its origin of production and in its aggressiveness to the environment, [ 24 ] complying with aspects of processes based on green chemistry.…”