Synthesis of poly(diethylaminoethyl methacrylate-co-2,2,6,6-tetramethyl-4-piperidyl methacrylate)s and their segmental motion study

Naveed, Kaleem‐ur‐Rahman; Wang, Li; Teng, Lidong; Uddin, Md Alim; Fahad, Shah; Nazir, Ahsan

doi:10.1007/s00396-020-04717-1

Cited by 6 publications

(2 citation statements)

References 61 publications

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“…43 The electro-activity of stable radical-containing polymers through the self-exchange interactions is monitored in electrolyte-supported systems by considering redox reactions between the pendant radical functionalities. 43,46 The selfexchange between the radicals strongly depends on their closer proximity. 47 The scope of self-exchange interaction also relies on the conformational change of radical-containing polymer chains, which can be determined by CV.…”

Section: Resultsmentioning

confidence: 99%

Dynamics in Controllable Stimuli-Responsive Self-Assembly of Polymer Vesicles with Stable Radical Functionality

Uddin

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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Self-assembled polymer vesicles have emerged as exciting and promising materials for their potential application in drug delivery, but the dynamics of stimuli-responsive polymers in these areas with pendant functionality in order to understand the structure–property relationship under different physicochemical conditions is still open to discussion. In this work, nitroxide radical-containing copolymers were synthesized and utilized to investigate local dynamics in their vesicular assemblies. Herein, electron paramagnetic resonance (EPR) spectroscopy was applied to reveal the smart supramolecular vesicular structure and polymer chain dynamics in stimuli-responsive controlled assemblies by considering molecular-level interactions. These interactions and dynamics were dependent on the microenvironment of the assemblies, which might be affected by physicochemical parameters such as radical concentration, pH, redox agent, polarity, and viscosity. These observations help to accomplish quantitative insights into the stimuli-responsive colloidal vesicular assemblies. The vesicles were used as an anticancer drug carrier, which showed high drug loading efficiency (63.65%). The reduction-responsive prompt disassembly accelerated the release. Furthermore, the biocompatibility and anticancer activity were examined by cellular experiments against normal fibroblasts (L929) and human cervical cancer (HeLa) cell lines, respectively. The results demonstrate that this effort provides an easy strategy for designing controllable stimuli-responsive polymer nanosystems which promotes their promising application in cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Dynamics in Controllable Stimuli-Responsive Self-Assembly of Polymer Vesicles with Stable Radical Functionality

Uddin

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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“…In recent years, a number of papers have been published dealing with the dynamics of polymers in aqueous systems by spin‐label EPR. For example, poly(acrylic acid)s, [ 40 ] poly(styrene‐co‐maleic acid)s, [ 41 ] ethylene‐glycol based polymers, [ 42 ] and poly(2‐(diethylamino)ethyl methacrylate) [ 43 ] were spin‐labeled to understand the segmental dynamics of polymer chains in aqueous solution. Furthermore, inter‐polymer complexes of spin‐labeled poly(styrene‐co‐maleic acid) with polyethylene glycols were studied.…”

Section: Introductionmentioning

confidence: 99%

Local Chain Dynamics in Polyelectrolyte Multilayers of Chitosan and Spin‐Labeled Poly(ethylene‐alt‐maleic acid)

Lappan

Naas

Scheler

2023

Macro Chemistry & Physics

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The cationic charged chitosan and the weak polyacid poly(ethylene‐alt‐maleic acid) are used to build polyelectrolyte multilayers (PEMs). To study the rotational dynamics of the polymer backbone in the swollen state of the PEMs using electron paramagnetic resonance spectroscopy, a nitroxide spin‐label is covalently attached to the polyacid. It is found that spectra of PEMs with even number of layers show a superposition of two spectral components: a major, slow‐motion component, which arises from chain segments intrinsically compensated by protonated amino groups of the chitosan, and a minor, fast‐motion component, which is assumed to originate from loops and tails of the polyacid chain located at the surface of the PEMs. The dissociated acid groups in the loops and tails are extrinsically compensated by small counterions and the rotational mobility of these chain segments is consequently much higher compared to chain segments interacting with the oppositely charged chitosan.

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Preparation of thermosensitive PNIPAm- based copolymers with tertiary amino and hydroxyl monomer for cell attachment and detachment study

Kuo

Mei

Chang-chun

et al. 2023

European Polymer Journal

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Synthesis of poly(diethylaminoethyl methacrylate-co-2,2,6,6-tetramethyl-4-piperidyl methacrylate)s and their segmental motion study

Cited by 6 publications

References 61 publications

Dynamics in Controllable Stimuli-Responsive Self-Assembly of Polymer Vesicles with Stable Radical Functionality

Dynamics in Controllable Stimuli-Responsive Self-Assembly of Polymer Vesicles with Stable Radical Functionality

Local Chain Dynamics in Polyelectrolyte Multilayers of Chitosan and Spin‐Labeled Poly(ethylene‐alt‐maleic acid)

Preparation of thermosensitive PNIPAm- based copolymers with tertiary amino and hydroxyl monomer for cell attachment and detachment study

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