The high level of reactive oxygen species (ROS) and bacterial
infection
impede wound healing of the diabetic wound. Here, benefiting from
the antioxidation effects of tannic acid (TA) and ROS-responsive phenylborate
ester (PBAE), a series of ROS-responsive anti-inflammatory TA-conjugated
nanoparticle hydrogels (PPBA-TA-PVA) can be obtained by conveniently
mixing TA, phenylboric acid modified polyphosphazene (PPBA), and poly(vinyl
alcohol) (PVA). The obtained PPBA-TA-PVA hydrogels could effectively
inhibit the growth of Escherichia coli (antibacterial
rate = 93.1 ± 1.1%) within 4 h and effectively scavenge both
2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and •OH radicals in vitro. Besides, the cell migration rate of HDFa cells
treated with PPBA-TA-PVA hydrogels (84.2 ± 4.6%) was twice the
rate of normal cells (43.8 ± 8.1%) after 24 h of cocultivation.
The clinical relevance was demonstrated further by assessing the PPBA-TA-PVA
hydrogels in full-thickness excisional wounds in a streptozotocin
(STZ)-induced diabetic rat model. The PPBA-TA-PVA hydrogels could
act as effective ROS-scavenging agents to alleviate inflammation and
accelerate wound closure by decreasing the proinflammatory cytokines
(IL-6, IL-1β) and increasing the gene expression of TGF-β1,
COL-1, and COL-3, which resulted in faster re-epithelialization and
increased formation of granulation tissue.
The rise of miniaturized, integrated, and functional electronic devices has intensified the need for heat dissipation. To address this challenge, it is necessary to develop novel thermally conductive polymer composites as packaging materials. In this paper, a number of factors for the construction and design of thermally conductive polymers are concluded. Special attention is focused on the analysis and comparison of the thermally conductive composites prepared by various fillers or strategies to provide guidelines and references for future design of composite materials. The current commonly used preparation strategies of thermally conductive polymer are summarized, such as using a variety of fillers, vacuum filtration, template method, and so on. The challenges of thermally conductive polymer composites are finally sketched. This review can inspire the design of polymer composites with brilliant thermal conductivity.
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